نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

Journal: :Journal of immunology 2010
Alana A Shigeoka Amanpreet Kambo John C Mathison Andrew J King Wesley F Hall Jean da Silva Correia Richard J Ulevitch Dianne B McKay

Nucleotide-binding oligomerization domain (Nod) 1 and Nod2 are members of a family of intracellular innate sensors that participate in innate immune responses to pathogens and molecules released during the course of tissue injury, including injury induced by ischemia. Ischemic injury to the kidney is characterized by renal tubular epithelial apoptosis and inflammation. Among the best studied in...

2013
Shu Q. Liu Derek Roberts Alexei Kharitonenkov Brian Zhang Samuel M. Hanson Yan Chun Li Li-Qun Zhang Yu H. Wu

Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mo...

Journal: :Cancer Research 2021

Abstract In this issue of Cancer Research, Zhou and colleagues investigate the role acute kidney injury (AKI) AKI-associated systemic inflammation in development cancer. They demonstrate a positive association between formation clear-cell renal cell carcinoma AKI induced by ischemia-reperfusion genetically modified mice. parallel with emergence tumors, mice ischemic develop associated tissue in...

Journal: :American journal of physiology. Renal physiology 2008
Lisa M Curtis Sifeng Chen Bo Chen Anupam Agarwal Christopher A Klug Paul W Sanders

The kidney is capable of regeneration following injury, particularly following acute insults. Although the mechanisms underlying cellular regeneration are incompletely understood, emerging evidence suggests a role for cells of renal origin in the repair and replacement of damaged renal tubule cells. The overall hypothesis of this study is that native kidney cells that reside in a niche in the k...

Journal: :journal of research in medical sciences 0
behrooz heydari hossein khalili mohammad?taghi beigmohammadi alireza abdollahi iman karimzadeh

background: the most common clinical indication of aminoglycosides (ag) is the treatment of serious gram?negative infections.the aim of this study was to evaluate plausible effects of atorvastatin on the biomarkers of acute kidney injury (aki) in patients receiving amikacin. materials and methods: in this double?blinded randomized clinical trial, fifty patients (25 in each group) receiving amik...

Journal: : 2022

Objective: Ischemic/reperfusion (I/R) causes tissue injury and the leading cause of acute kidney injury. In this study, we aimed to investigate effects long short-term usage ALA DHLA on oxidative stress markers in experimental renal ischemia-reperfusion model. Methods: Forty male rats (250 300 gr) were divided into 5 groups: control; I/R group; long-term ALA+IR DHLA+IR group. Ischemia was carri...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016
Fengbao Luo Jian Shi Qianqian Shi Xianlin Xu Ying Xia Xiaozhou He

Tissue hypoxia/ischemia is a pathological feature of many human disorders including stroke, myocardial infarction, hypoxic/ischemic nephropathy, as well as cancer. In the kidney, the combination of limited oxygen supply to the tissues and high oxygen demand is considered the main reason for the susceptibility of the kidney to hypoxic/ischemic injury. In recent years, increasing evidence has ind...

Journal: :American journal of physiology. Renal physiology 2014
Punithavathi Ranganathan Calpurnia Jayakumar Riyaz Mohamed Neal L Weintraub Ganesan Ramesh

Recent studies show that guidance molecules that are known to regulate cell migration during development may also play an important role in adult pathophysiologic states. One such molecule, semaphorin3A (sema3A), is highly expressed after acute kidney injury (AKI) in mice and humans, but its pathophysiological role is unknown. Genetic inactivation of sema3A protected mice from ischemia-reperfus...

Ardeshir Talebi , Effatsadat Vafamand , Hossein Jahani-Azizabadi , Lotfali Bolboli , Mehdi Nematbakhsh,

Introduction: Renal ischemia reperfusion (I/R) caused kidney injury gender dependently. High fat diet (HFD) contributes the development of renal dysfunction. L-arginine (L-arg) and regular exercise are recognized to be protective in I/R and lipotoxicity. We compared the role of aerobic exercise and L-arg supplementation against renal I/R in male and female rats fed with HFD. Methods: 54 adult ...

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