نتایج جستجو برای: acute kidney injury adipose tissue ischemia

تعداد نتایج: 1734170  

Journal: :The Journal of clinical investigation 2014
Guofeng Gao Weiwei Wang Raghu K Tadagavadi Nicole E Briley Michael I Love Barbara A Miller W Brian Reeves

Ischemia is a leading cause of acute kidney injury. Kidney ischemia is associated with loss of cellular ion homeostasis; however, the pathways that underlie ion homeostasis dysfunction are poorly understood. Here, we evaluated the nonselective cation channel transient receptor potential melastatin 2 (TRPM2) in a murine model of kidney ischemia/reperfusion (I/R) injury. TRPM2-deficient mice were...

2017
Serhat Huseyin Orkut Guclu Volkan Yüksel Gulen Sezer Alptekin Erkul Nuray Can Fatma Nesrin Turan Suat Canbaz

Objective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat ao...

Journal: :Acta clinica Croatica 2015
Mine Yilmaz Rasim Mogulkoc Abdulkerim Kasim Baltaci

Renal ischemia-reperfusion directly affects glomerular and tubular epithelium. Oxygen free radicals have a significant part in the pathophysiology of renal ischemia-reperfusion injury. The present study aimed to identify the effects of 3-week zinc, melatonin, and zinc + melato- nin supplementation on malondialdehyde (MDA) levels in tissue and plasma and glutathione levels (GSH) in erythrocytes ...

2009
Bharath K. Atthe Andriy M. Babsky Paige N. Hopewell Carrie L. Phillips Bruce A. Molitoris Navin Bansal

Atthe BK, Babsky AM, Hopewell PN, Phillips CL, Molitoris BA, Bansal N. Early monitoring of acute tubular necrosis in the rat kidney by Na-MRI. Am J Physiol Renal Physiol 297: F1288–F1298, 2009. First published September 2, 2009; doi:10.1152/ajprenal.00388.2009.— Reabsorption of water and other molecules is dependent on the corticomedullary sodium concentration gradient in the kidney. During the...

Journal: :Journal of the American Society of Nephrology : JASN 2007
Tokunori Yamamoto Eisei Noiri Yoshinari Ono Kent Doi Kousuke Negishi Atsuko Kamijo Kenjiro Kimura Toshiro Fujita Tsuneo Kinukawa Hideki Taniguchi Kazuo Nakamura Momokazu Goto Naoshi Shinozaki Shinichi Ohshima Takeshi Sugaya

Fatty acid-binding proteins (FABPs) bind unsaturated fatty acids and lipid peroxidation products during tissue injury from hypoxia. We evaluated the potential role of L-type FABP (L-FABP) as a biomarker of renal ischemia in both human kidney transplant patients and animal models. Urinary L-FABP levels were measured in the first urine produced from 12 living-related kidney transplant patients im...

Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...

Journal: :The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2012
Akın Onder Murat Kapan Metehan Gümüş Hatice Yüksel Abdullah Böyük Harun Alp Mustafa Kemal Başarili Uğur Firat

BACKGROUND/AIMS Mesenteric ischemia/reperfusion injury induces a systemic response and releases harmful substances that may affect distant organs such as the lung, liver and kidney. We designed this study to determine if curcumin has protective effects against mesenteric ischemia/reperfusion injury and mesenteric ischemia/reperfusion-induced intestinal and distant organ injury. METHODS Forty ...

Journal: :Nature Communications 2023

Abstract Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney molecule-1 (KIM1) is dramatically upregulated in renal tubules upon injury, acts as a biomarker for various diseases. However, the exact role underlying mechanism of KIM1 progression AKI remain elusive. Herein, we report that tubular specific knockout Kim1 attenuates cisplatin- or ischemia/reperfusion-induced male ...

Journal: :Veterinary pathology 2017
S K Bland C W Schmiedt M E Clark J DeLay D Bienzle

Sensitive markers to detect acute kidney injury (AKI) in cats are lacking. Kidney injury molecule-1 (KIM-1) is a promising marker of acute tubular injury in humans, and sequence and structure of feline KIM-1 have been determined. KIM-1 is shed into urine of cats with natural AKI. The objectives of this study were to characterize temporal and cellular expression of KIM-1 in kidneys from cats wit...

Journal: :Blood 2011
Aparna Krishnamoorthy Amrendra Kumar Ajay Dana Hoffmann Tae-Min Kim Victoria Ramirez Gabriela Campanholle Norma A Bobadilla Sushrut S Waikar Vishal S Vaidya

Ischemia/reperfusion (I/R) injury in the kidney is a major cause of acute kidney injury (AKI) in humans and is associated with significantly high mortality. To identify genes that modulate kidney injury and repair, we conducted genome-wide expression analysis in the rat kidneys after I/R and found that the mRNA levels of fibrinogen (Fg)α, Fgβ, and Fgγ chains significantly increase in the kidney...

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