Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-...

With a newly developed turbidometric method, concana valin A was shown to agglutinate normal lymphocytes, lym phoma cells, and leukemic cells from chronic lymphocytic leukemia and from acute myelocytic and lymphocytic leuke mia. However, there was a marked difference in the kinetics of this agglutination process. Leukemic blast cells and cells from a patient with convoluted lymphoma agglutinate...

The sialic acid content of erythrocytes from healthy individuals of different blood types and of patients with known hematological disorders has been determined. The sialic acid was completely released enzymatically with sialidase and quantitated by the thiobarbituric acid method. The sialic acid content of erythrocytes was constant irrespective of ABO blood type, or anticoagulant used; viz, 0....

At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...

Nonhuman primate antisera defining leukemia-associ ated and normal Tand B-lymphocyte-associated anti gens were used to characterize serologically the cells from acute myelomonocytic leukemia (AMML) and chronic myelogenous leukemia patients in blast crisis (CML-BC). Earlier studies demonstrated that nonhuman primate an tisera to chronic lymphocytic leukemia, acute myelogen ous leukemia, and chro...

We investigated the frequency of mutations activating RAS oncogenes in human lymphoid malignancies, including B- and T-cell-derived acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma. By the polymerase chain reaction/oligonucleotide hybridization method, DNA from 178 cases was analyzed for activating mutations involving codons 12 and 61 of the HRAS, KRAS and NR...

Introduction: This study is aimed to assess the prevalence and characteristics of head and neck lymphoma in a defined group of an Iranian population.   Materials and Methods: In this retrospective study, 126,450 biopsy reports from two referral Pathology Departments, (Tehran, the capital of Iran) were evaluated. In cases with head and neck lymphoma, other variables such as age, sex, specific lo...

Population-based study on the impact of the familial form of Waldenström macroglobulinemia on overall survival Waldenström macroglobulinemia (WM) is a chronic lymphoprolifer-ative disorder (LP) characterized by an immunoglobulin M monoclonal gammopathy in the presence of lymphoplasmacytic lymphoma (LPL) in the bone marrow. 1 We have previously shown in a large population-based study that first-...

Guillain-Barre syndrome, an acute or subacute inflammatory demyelinating polyradiculoneuropathy, usually causes ascending paralysis, areflexia, and sensory disturbances. l A similar syndrome, more chronic and sometimes relapsing, has been called chronic inflammatory demyelinating polyneuropathy.2 Thought to have an immunologic cause, Guillain-Barre syndrome can be found in association with infe...

abstract objective fever and neutropenia are a common complication of chemotherapy in cancer. it is usually managed by hospitalization and empiric administration of antibiotics. use of fluroquinolones is limited because of joint/cartilage toxicity. this study attempted to compare the efficacy of oral ciprofloxacin with intravenous ceftazidim in low risk febrile neutropenic lymphocytic leukemia....