Abstract For the integrate-and-fire model and the Hodgkin–Huxley model, we consider how current inputs including α-wave and square-wave affect their outputs. Firstly the usual approximation is employed to approximate the models with current inputswhich quantitatively reveals the difference between instantaneous and noninstantaneous (current) inputs. When the rising time of α-wave inputs is long...

allogeneic hematopoietic stem cell transplantation (hsct) is the most effective therapy to prevent relapse in acute lymphocytic leukemia (all). this benefit is affected by non-relapse mortality (nrm) due to complications such as graft versus host disease (gvhd). a new approach in analyzing time-dependent covariates in competing risks is landmark analysis. so, the aim of this study is to evaluat...

In 1928, a pathologist at Bellevue Hospital in New York City named Maurice Richter performed an autopsy on a 46-year-old man. The patient had a 2-month history of abdominal pain and weight loss and was admitted to the hospital, where he died. He was found to have lymphatic leukemia and reticulum cell sarcoma.[1] In 1964, the term “Richter's syndrome” (or “Richter's transformation”) was introduc...

Forty patients were enrolled in this phase 2 study combining radioimmunotherapy (RIT) using yttrium-90-ibritumomab-tiuxetan (15 MBq [0.4 mCi]/kg) with reduced-intensity conditioning (RIC) using fludarabine (90 mg/m(2)) and 2 Gy total body irradiation followed by allogeneic hematopoietic cell transplantation (HCT) from related (n = 13) or unrelated (n = 27) donors for the treatment of advanced n...

Richter transformation is defined as a diffuse large cell lymphoma, occurring by transformation of chronic lymphocytic leukemia (CLL). We present a 64-year-old man with a history of CLL and a left parieto-occipital transtentorial extra-axial mass. The patient underwent CT and MR imaging, demonstrating a large dural-based mass with extracranial extension, which occluded the left transverse sinus...

light of the results of the French study, one can only agree with the recommendation of Lepretre et al that FCA should not be used for the treatment of CLL outside of clinical trials. The question of whether alemtuzumab should no longer be used in any chemoimmu-notherapy is an entirely different issue. It should be emphasized that a recent random-ized trial showed that the second-line use of fl...

The (9;22) translocation which produces the Philadelphia (Ph1) chro mosome activates the ahi oncogene from chromosome 9 by recombination with the her gene from chromosome 22. This fusion gene is transcribed into a new 8.5-kilobase chimeric niRN A which is translated into a novel M, 210,000 fusion protein which has a protein tyrosine kinase activity that is greatly increased in comparison to the...

BACKGROUND Advances in the treatment of childhood hematologic malignancies have led to improvements in survival for several of these conditions during the past few decades, but most population-based survival data available to date refer only to patients diagnosed up to the mid-1990s. METHODS We used period analysis to assess trends in 5- and 10-year survival in US patients younger than 15 yea...

Note 3q27 rearrangements occur in distinct clinicopathological entities of B-cell non Hodgkin lymphoma (NHL), including diffuse large cell lymphoma (DLCL), follicle centre cell lymphoma (FCCL) and marginal zone B-cell lymphoma (MZBCL) in the REAL classification; very rare cases were also reported with mantle cell lymphoma and chronic lymphocytic leukemia. 3q27 breaks are usually, but not invari...