Submit Manuscript | http://medcraveonline.com Abbreviations: α-syn: α-synucleinopathies; Aβ: Amyloid Beta; AD: Alzheimer’s Disease; ALL: Acute Lymphoblastic Leukemia; ALS: Amyotrophic Lateral Sclerosis; BBB: Blood Brain Barrier; BPB: Brain Protective Barriers; CAR: Chimeric Antigen Receptor; CLL: Chronic Lymphocytic Leukemia; CNS: Central Nervous System; CSF: Cerebro-Spinal Fluid; CTLA: Cytotox...

AIM To investigate the time trends of leukemia and lymphoma in Croatia from 1988-2009, compare them with trends in other populations, and identify possible changes. METHODS The data sources were the Croatian National Cancer Registry for incidence data, Croatian Bureau of Statistics for the numbers of deaths, and United Nations population estimates. Joinpoint regression analysis using the age-...

This is a case report of a 12-year-old male who developed acute lymphocytic leukaemia (ALL) 8 years after a diagnosis of Hodgkin's disease (HD) had been made. During the 8 years, intensive radiotherapy and a single dose of cyclo¬phosphamide was given as treatment for HD. Review of the Kenyatta National Hospital (KNH) cancer registry records reveals that this is one of 498 patients diagnosed his...

Patients with lymphoma who have experienced a first relapse or progression and have disease deemed sensitive to salvage chemotherapy nevertheless have a high likelihood of having a second relapse. To decrease the likelihood of a second relapse after high-dose therapy (HDT) and autologous stem cell transplantation (ASCT), interferon (IFN) α-2b was given in a prospective randomized international ...

BACKGROUND The subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China. METHODS Lymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification. RESULTS From January 2000 to December 2008...

Richter's transformation (RT) represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). CLL/SLL may convert also to Hodgkin's lymphoma, the so-called Hodgkin's variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients...

introduction : acute lymphoblastic leukemia (all) and non-hodgkin's lymphoma (nhl) are the most common malignancies in children and adolescents. therapies such as corticosteroids, cytotoxic and radiotherapy will have harmful effect on bone mineral density (bmd) which can lead to increased possibility of osteoporosis and pathological fractures. subjects and methods: this 3-year cross-sectional s...

Lymphocytic hypophysitis represents a difficult diagnostic and therapeutic challenge. The clinical presentation of this inflammatory condition may mimic that pituitary adenoma with apoplexy. We report case 45 years old male patient acute adrenal crisis complicating chronic hypopituitarism secondary to lymphocytic hypophysitis. was managed acutely high dose steroids supportive measures, is curre...

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common form of leukemia affecting adults in Europe and North America. Large B-cell lymphoma known as Richter's syndrome (RS) may develop approximately in 3-15 % patients. Furthermore, other hematological malignancies may also occur as RS variants, among them-Hodgkin lymphoma (HL). CLL/SLL transformation into HL...

associations of some hematological and lymphatic diseases with sex and abo and rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in tehran. highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplas...