Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have d...

Acute lymphocytic leukemia (ALL) is one of the frequent malignancies in pediatrics and involves bone marrow and extramedullary sites. Proptosis as extramedullary involvement of leukemia usually present in acute and chronic myeloid leukemia. It is extremely rare for ALL to present initially as proptosis.Here, a-21-month-old boy was presented with proptosis without any associated symptoms except ...

Cyclic adenosine monophosphate response-element binding protein (CREB) is a nuclear protein that regulates expression of genes that control cell proliferation, differentiation, and survival. To analyze CREB expression in leukemia cells, we conducted Western blot analysis of bone marrow cells obtained from patients with acute lymphoblastic leukemia, patients with acute myeloid leukemia, and pati...

Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. Various drugs targeting this pathway have entered clinical trials. To evaluate CXCR4 imaging in acute myeloid leukemia, we first tested CXCR4 expression in pat...

myeloid sarcoma or granulocytic sarcoma (gs) is a rare disease with poor prognosis. it is characterized by the occurrence of tumor masses at an extra-medullary tissue. it is composed of myeloblastic cells and usually occurs in association with acute myeloid leukemia. because of its nonspecific clinical and radiologic findings, its diagnosis might be challenging. it might be more commonly found ...

Myeloid sarcoma in acute myeloid leukemia has been clearly defined by the World Health Organization but studies regarding the prevalence and the prognostic impact of extramedullary acute myeloid leukemia have not been conducted. We performed (18)Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography scans in 10 patients with de novo and relapsed acute myeloid leukemia and histolo...

Mediastinal Myeloid Sarcoma is a rare entity. Here we present case of 28-year-old gentleman, who first presented with mediastinal mass and was clinically considered lymphoblastic lymphoma. He diagnosed initially as having T lymphoma on trucut biopsy. After one month patient Acute myeloid leukemia peripheral smear bone marrow examination confirmed the help flow cytometry. The biopsy slides from ...

Nitric oxide (NO) is a molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS). It is a free radical, producing many reactive intermediates that account for its bioactivity. Sustained induction of the inducible form of NOS (iNOS) in chronic inflammation may be mutagenic, through NO-mediated DNA damage or hindrance to DNA repair, and thus potentially ca...

Acute myeloid leukemia is characterized by a malignant proliferation of hematopoietic progenitor cells of the myeloid lineage. The lack of differentiation of precursor cells causes their inability to function normally and the disruption of normal hematopoiesis. This review provides a brief overview of the most important pharmacological strategies that impact on acute myeloid leukemia cure rates...