a 61-year-old female presented with complaints of fever, general weakness and hepatosplenomegaly. she had a history of nonfamilial peripheral neurofibromatosis diagnosed as von recklinghausen's disease since 30 years previous. physical examination was remarkable for skin colored cutaneous circumscribed nodules which appeared soft to the touch in both arms, the upper part of her abdomen, back, a...

the significance of immunophenotyping is growing day by day. it provides basic information in regard to classification and prognosis of acute leukemia which helps the management of patients. this study was conducted to identify cd markers in leukemic patients admitted to tabriz, in northwestern iran. immunophenotyping of 60 patients with acute leukemia was determined. patients with acute myelog...

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

Human T-cell lymphotropic virus type 1 , 2 (HTLV-1, 2) is endemic in Particular Areas of the world in which it is associated with myeloid leukemia.In this study, we described the prevalence of HTLV-1, 2 in myeloid leukemia and Mycobacterium Tuberculosis in Iran. We have worked with tissue and blood samples for 2 years. These were the same samples which were positive for myeloid leukemia, Mycoba...

The significance of immunophenotyping is growing day by day. Itprovides basic information in regard to classification and prognosisof acute leukemia which helps the management of patients. Thisstudy was conducted to Identify CD markers in leukemic patientsadmitted to Tabriz, in northwestern Iran. Immunophenotyping of 60patients with acute leukemia was determined. Patients with acutemyelogenous ...

background : according to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. this study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. methods :we conducted a web-based search for all peer ...

Myeloid/lymphoid neoplasms with FGFR1 rearrangement (MLN-FGFR1) comprise a heterogeneous group of that can present as myeloproliferative neoplasm, myelodysplastic/myeloproliferative acute myeloid leukemia, T or B lymphoblastic leukemia/lymphoma, mixed phenotype leukemia. The overall outcome these is poor, and patients often show cytogenetic evolution gain additional chromosomal abnormalities le...

background :according to numerous studies, fms-like tyrosine kinase 3, internal tandem duplication, and the d835 mutation are associated with a poor prognostic clinical outcome in acute myeloid leukemia patients. detection of the fms-like tyrosine kinase 3 mutation in patients who present with normal karyotype acute myeloid leukemia helps in both the understanding of the disease and the treatme...