Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxi...

Explanation.................................................................................................... 161 Evaluation for acceptable daily intake .......................................................... 161 Biochemical aspects ................................................................................ 162 Absorption, distribution and excretion ......................................

BACKGROUND To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era of daily image guidance (IG-IMRT). METHODS A set of DVSE was recorded from V25 to V75 (increments of 5Gy) (both in % and in cc) for 180 men. The rAUC was calculated for doses...

Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxi...

Introduction: Nonsteroidal anti-inflammatory drugs are the most commonly used drugs to reduce pain and inflammation. Aceclofenac is a newer derivative of diclofenac with less gastrointestinal complications. The objective of the present study was to evaluate the toxicity profile of sustain release aceclofenac injection in rats at three dose levels, ranging from 2 to 10 mg/kg body weight. Mater...

BACKGROUND Increasing clinical data supports a low α/β ratio for prostate adenocarcinoma, potentially lower than that of surrounding normal tissues. A hypofractionated, weekly radiation therapy (RT) schedule should result in improved tumour control, reduced acute toxicity, and similar or decreased late effects. We report the toxicity profile of such treatment. MATERIALS AND METHODS We conduct...

BACKGROUND The features of acute classical recreational drugs or new psychoactive substances (NPS) toxicity fall into three broad groups: (i) stimulant; (ii) hallucinogenic and (iii) depressant. Currently, there is no information available on healthcare professionals knowledge/confidence in managing the acute toxicity related to NPS use. AIM We have compared knowledge and confidence of managi...

A.1 Toxicity to Birds / Reptiles ......................................................................................... 2 A.1.1 Birds: Acute Oral Studies .................................................................................... 2 A.1.2 Birds: Subacute Dietary Studies .......................................................................... 4 A.1.3 Birds: Chronic Studies.............