The disintegrin metalloproteases (or ADAMs) are membrane-anchored glycoproteins that have been implicated in cell-cell or cell-matrix interactions and in proteolysis of molecules on the cell surface. The expression and/or the pathophysiological implications of ADAMs are not known in intestinal epithelial cells. Therefore, our aim was to investigate the expression and the role of ADAMs in intest...

PURPOSE We have shown previously that exposure to anticancer drugs can trigger the activation of human epidermal receptor survival pathways in colorectal cancer (CRC). In this study, we examined the role of ADAMs (a disintegrin and metalloproteinases) and soluble growth factors in this acute drug resistance mechanism. EXPERIMENTAL DESIGN In vitro and in vivo models of CRC were assessed. ADAM-...

ADAM-15, with known zymogen, secretase, and disintegrin activities, is a catalytically active member of the ADAM family normally expressed in early embryonic development and aberrantly expressed in various cancers, including breast, prostate and lung. ADAM-15 promotes extracellular shedding of E-cadherin, a soluble ligand for the HER2/neu receptor, leading to activation, increased motility, and...

ADAM-10 (CDw156, CD156c, and kuzbanian) is a protein belonging to a superfamily of metalloproteases, enzymes capable of degrading the extracellular matrix. ADAMs have also been shown to be primarily involved in ectodomain cleavage. The aim of the study was to assess the expression and intracellular location of ADAM-10 in 104 primary skin melanomas and 16 metastatic lesions from regional lymph n...

Transient stability-constrained optimal power flow (TSCOPF) models comprehensively analyze the security and economic operation of systems. However, they require a high computational effort can suffer from convergence problems when applied to large This study analyzes performance eleven numerical integration algorithms ordinary differential equations that represent system dynamics in TSCOPF mode...

one of the most important doctrines in christianity is original sin. it has a key role in christian theology and was the concern of many christian thinkers during the history of christianity. the debates and disputes of christian theologians about it, especially in early history of christianity lead to take a formal position about it by the church. in sacred texts of muslims, especially in holy...

Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients.

in this paper, the (m+1)-step adams-bashforth, adams-moulton, and predictor-correctormethods are used to solve rst-order linear fuzzy ordinary dierential equations. the conceptsof fuzzy interpolation and generalised strongly dierentiability are used, to obtaingeneral algorithms. each of these algorithms has advantages over current methods. moreover,for each algorithm a convergence formula can b...