Arachidonic acid (ARA) metabolites produced by cyclo-oxygenase and lipoxygenase are important mediators maintaining physiological renal function. However, the effects of exogenous ARA on kidney function in vivo remain unknown. This study examined the effects of long-term oral ARA administration on normal renal function as well as inflammation and oxidative stress in aged rats. In addition, we m...

5-hydroxyeicosatetraenoic acid (5-HETE) and 5-hydroxyeicosapentaenoic acid (5-HEPE) are major metabolites produced by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) and eicosapentaenoic acid (EPA). Effects of hydroxides on endothelial cells are unclear, although 5-LOX is known to increase at arteriosclerotic lesions. To investigate the effects of hydroxides on human umbilical vein endothelia...

A study was conducted to determine the effects of dietary conjugated linoleic acid (CLA) and the ratio of linoleic:linolenic acid on long-chain polyunsaturated fatty acid status. Thirty-two 31-wk-old White Leghorn hens were randomly assigned to four diets containing 8.2% soy oil, 4.1% soy oil + 2.5% CLA (4.1% CLA source), 4.1% flax oil + 2.5% CLA, or 4.1% soy oil + 4.1% flax oil. Hens were fed ...

In this study, seasonal variations of fatty acid amounts in muscle tissues of Capoeta caelestis were investigated. We have found that the ω3 contents of C. caelestis in spring, summer, autumn and winter were 17.43%, 15.29%, 17.54%, 13.63% in female and 16.96%, 19.25%, 18.66%, 14.76% in male, respectively. The amounts of ω3 polyunsaturated fatty acids were higher than those of ω6 polyunsaturated...

Linoleic acid, with a DRI of 12-17g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually all commonly consumed foods. The concern with dietary linoleic acid, being the metabolic precursor of arachidonic acid, is its consumption may enrich tissues with arachidonic acid and contribute to chronic and overproduction of bioactive eicosanoids. Howeve...

A high phosphorus (HP) diet causes disorders of renal function, bone metabolism, and vascular function. We previously demonstrated that DNA microarray analysis is an appropriate method to comprehensively evaluate the effects of a HP diet on kidney dysfunction such as calcification, fibrillization, and inflammation. We reported that type IIb sodium-dependent phosphate transporter is significantl...

Long-chain (≥C20) polyunsaturated fatty acids (LC-PUFA), including eicosapentaenoic acid (EPA, 20:5n-3), arachidonic (ARA, 20:4n-6) and docosahexaenoic (DHA, 22:6n-3), are essential in multiple physiological processes, especially during early development of vertebrates. LC-PUFA biosynthesis is achieved by two key families enzymes, acyl desaturases (Fads) elongation very long-chain (Elovl). The ...

ba ckground: obesity is a consequence of the excessive accumulation of fat in adipose tissue which can result in significant morbidity and mortality. obesity is a major health problem in iran.  objective: the aim of this study was to investigate the  effects of  epa consumption on bmi  and  fasting blood sugar by fabp2 genotypes and pparα (leu162val, and g/c intron polymorphism) genotypes.   m ...