نتایج جستجو برای: adiponectin/ genetics
تعداد نتایج: 87060 فیلتر نتایج به سال:
background: polycystic ovary syndrome (pcos) is a complex disease having both genetic and environmental components and candidate genes on obesity and insulin metabolism have been hypothesized to be involved in its etiology. objective: we examined the possible association of adiponectin and insulin receptor gene polymorphisms with pcos. materials and methods: a total of 186 women with pcos using...
OBJECTIVE Adiponectin, a hormone secreted by adipose tissue, is of particular interest in metabolic syndrome, because it is inversely correlated with obesity and insulin sensitivity. However, it is not known to what extent the genetics of plasma adiponectin and the genetics of obesity and insulin sensitivity are interrelated. We aimed to evaluate the heritability of plasma adiponectin and its g...
To determine whether selected genes and plasma markers involved in energy homeostasis are associated with sleep disruption or duration adults HIV/AIDS. A sample of 289 HIV/AIDS wore a wrist actigraph for 72 h to estimate total time (TST) wake after onset (WASO). Twenty-three single nucleotide polymorphisms (SNP) spanning 5 (adiponectin [ADIPOQ], ghrelin [GHRL], leptin [LEP], peroxisome prolifer...
Polycystic ovarian syndrome can be defined as an endocrine disorder that most affects the reproductive system of women childbearing age; its causes are not exactly known. However, majority experts agree it is a multifactorial entity with multiple factors. Genetics becoming increasingly important. In recent years, several genes involved in pathogenic processes this have been identified. Within t...
OBJECTIVE Plasma adiponectin is strongly associated with various components of metabolic syndrome, type 2 diabetes and cardiovascular outcomes. Concentrations are highly heritable and differ between men and women. We therefore aimed to investigate the genetics of plasma adiponectin in men and women. METHODS We combined genome-wide association scans of three population-based studies including ...
Increased adiponectin levels have been shown to be associated with a lower risk of type 2 diabetes. To understand the relations between genetic variation at the adiponectin-encoding gene, ADIPOQ, and adiponectin levels, and subsequently its role in disease, we conducted a deep resequencing experiment of ADIPOQ in 14,002 subjects, including 12,514 Europeans, 594 African Americans, and 567 Indian...
OBJECTIVE This study investigated genetic determinants of adiponectin during pregnancy to reveal novel biology of adipocyte regulation. METHODS A genome-wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation. Variants reaching P < 5×10-5 for de novo genotyping in two replicatio...
BACKGROUND AND AIMS Adiponectin is an adipose-secreted protein that has been linked to changes in insulin sensitivity, high-density lipoprotein cholesterol levels, and inflammatory patterns. Although fenofibrate therapy can raise adiponectin levels, treatment response is heterogeneous and heritable, suggesting a role for genetic mediators. This is the first genome-wide association study of feno...
atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. disturbed adiponectin actions through its receptor, (adipor1 and adipor2) may be involved in atheros...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید