objective(s) bone marrow is the traditional source of human multipotent mesenchymal stem cells (mscs), but adipose tissue appears to be an alternative and more readily available source. in this study, rat adipose-derived stem cells (adscs) were induced to differentiate into schwann-like cells and compared with rat bone marrow stem cells (bmscs) for their schwann-like cells differentiation poten...

objective(s) it is believed that the mesenchymal stem cell (msc) differentiation and proliferation are the results of activation of wnt signaling pathway. on the other hand, lithium chloride is reported to be able to activate this pathway. the objective of this study was to investigate the effect of lithium on in vitro proliferation and bone differentiation of marrow-derived msc. materials and ...

background: characteristics of differentiated osteoblasts from adipose derived stem cells (adscs) in compared with isolated osteoblasts from normal bone such as calvaria are unknown. the aim of this study was determination and comparison of phenotypic characterization between differentiated osteoblasts from stem cells and calvaria osteoblasts in vitro . methods: in this study, mesenchymal stem ...

today’s tissue engineering is an important and interested method to treatment of  bone lesions so tissue engineering specialists and orthopedic surgeons are forced to serve as a safe alternative to current methods.the introduction ofa scaffoldthathas thebestefficiencyisamajor challengeto scientistsand researchersin this field.the aim ofthisstudy is to investigatethe polyaniline(pani) influence ...

introduction: multiple sclerosis (ms) has been recognized as a common neurodegenerative disease that occurs after an auto reactive t cells against myelin antigens.  demyelination and inflammation are the main features of this disease. the anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (bm-mscs) have been considered as a suitable treatment against autoi...

several sources were introduced for cell therapy after neurotrauma. there are some evidences that quiescent stem cells are located in the various regions of the adult mammalian brain including cortex, hippocampus, amygdala and striatum. but more study is needed to identify the characteristics of these cells. in the present study we investigated the possibility of isolating neural stem cells fro...

in worldwide, an estimated 40 cases per 1 million people reported with new spinal cord injuries each year. people with spinal cord injuries suffer from severe physical, psychological, social and economic problems. damaged or lost cells can't be replaced when the spinal cord is injured; therefore, its function becomes disturbed permanently. despite the significant advances in the understand...

intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...

background & aim: low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. present therapies for intervertebral disc (ivd) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. they are found in multicellular organisms. in mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. in ad...