BACKGROUND The role of adjuvant stereotactic radiosurgery (SRS) and fractionated radiotherapy (XRT) are unknown in patients with resected meningiomas. OBJECTIVE To identify patterns of care and outcomes of adjuvant radiotherapy for meningiomas in the Linked Surveillance, Epidemiology, and End Results (SEER) Medicare data. METHODS A total of 1,964 patients older than 66 years included in the...

background: chemotherapy-induced amenorrhea is one of long term side effects of adjuvant chemotherapy in patients with breast cancer which may interfere with their future reproductive function. although amenorrhea is well recognized, the actual incidence following taxanes remains uncertain. methods: in a cross sectional study, we identified breast cancer patients aged 45 years or younger who we...

Transitional cell carcinoma of the bladder represents the second most common genitourinary malignancy [1]; the clinical approach to muscle-invasive disease has been modified in the last decade, considering the important role of multidisciplinary team, including surgeon, oncologist and radiotherapist. In fact, despite relevant progress in surgical management of these patients, the global prognos...

Abstract Adjuvants play a critical role in activating innate cells, which can shape the subsequent adaptive immune response including durability. The RV144 HIV-1 Vaccine Phase 3 Trial tested ALVAC ®DNA (prime) and gp120 subtype B/subtype E (AIDSVAX ®B/E) protein as boost. Although, vaccine regimen showed modest 31.2% efficacy with antibodies to V1V2 region one of correlates protection, response...

BACKGROUND The aim of this study is to investigate which reconstructive route is most appropriate for patients undergoing an esophagectomy for esophageal cancer. METHODS Clinical data on 110 patients were retrospectively collected by reviewing their medical charts. In order to evaluate the effects of adjuvant radiotherapy, patients were interviewed about the adverse side effects they experien...

The aim of the present study was to delineate the therapeutic effect of a Helicobacter pylori vaccine with chitosan as an adjuvant, as well as to identify the potential mechanism against H. pylori infection when compared with an H. pylori vaccine, with cholera toxin (CT) as an adjuvant. Mice were first infected with H. pylori and, following the establishment of an effective infection model, wer...

Is there a range of time for initiation of adjuvant chemotherapy in patients with malignancy? Adjuvant treatment is an important therapeutic modality particularly in the treatment of breast cancer and coloreclal cancer which are also among the most common cancers in adult population. Meta-analysis results of adjuvant trials has shown that adjuvant chemotherapy increases disease free survival an...