UNLABELLED No test currently exists for molecular imaging of pulmonary arterial hypertension (PAH). Adrenomedullin is a vasodilator peptide predominantly cleared by pulmonary endothelial receptors. We developed a linear adrenomedullin derivative radiolabeled with (99m)Tc ((99m)Tc-AM-L) for imaging of pulmonary circulation and tested its capacity to detect anomalies of pulmonary circulation caus...

BACKGROUND Hepatic sinusoidal resistance is regulated by vasoactive factors including endothelin-1 (ET-1) and nitric oxide (NO). In the absence of NO, vasoconstrictor response to endothelin is expected to predominate. Therefore, we hypothesized sensitivity to endothelin to be increased in mice lacking the endothelial cell NO synthase gene. Response of vascular resistance to endothelin was asses...

Abstract. In a vacuum spacetime equipped with the Bondi’s radiating metric which is asymptotically flat at spatial infinity including gravitational radiation (Condition D), we establish the relation between the ADM total energy-momentum and the Bondi energy-momentum for perturbed radiative spatial infinity. The perturbation is given by defining the “real” time the sum of the retarded time, the ...