Traditionally, researchers studying the vasculature examine either the biology of the large, arterial, high-pressure vessels or the resistance-regulating (arteriolar) or microvessels (capillaries), or less commonly, the venous, lowpressure vasculature. The lymphatic vasculature gets far less attention by the cardiovascular research community. This is despite the fact that the lymphatics play ve...

Blood samples are used as a biological source to discover biomarkers of hematological and non-hematological disorders. The present study shows the impact of different experimental conditions associated with cell lysis buffer, TRI-reagent protocol and blood cell storage buffer and their correlation with the quantity, quality and Adrenomedullin gene expression levels of total RNA when RT-PCR tech...

Adrenomedullin (AM) exerts profound natriuretic and vasodilatory effects in conscious animals. This newly discovered hormone also acts in the central nervous system to inhibit water drinking and in the pituitary gland to reduce basal and stimulated ACTH release. We investigated whether the natriuretic action of AM in kidney was matched by a central nervous system action to decrease salt intake....

We extend the idea and techniques in [14] to study variational effect of the boundary geometry on the ADM mass of an asymptotically flat manifold. We show that, for a Lipschitz asymptotically flat metric extension of a bounded Riemannian domain with quasi-convex boundary, if the boundary mean curvature of the extension is dominated by but not identically equal to the one determined by the given...

We analyze the ghost issue in the recently proposed models of non-linear massive gravity in the ADM formalism. We show that, in the entire two-parameter family of actions, the Hamiltonian constraint is maintained at the complete non-linear level and we argue for the existence of a nontrivial secondary constraint. This implies the absence of the pathological Boulware-Deser ghost to all orders. T...

Abstract Agonist bias occurs when different ligands produce distinct signalling outputs acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous agonist with consequences for calcitonin receptor-like receptor, CLR. By switching receptor-activity modifying protein (RAMP) associated CLR ...

We find a general principle which allows one to compute the area of the horizon of N=2 extremal black holes as an extremum of the central charge. One considers the ADM mass equal to the central charge as a function of electric and magnetic charges and moduli and extremizes this function in the moduli space (a minimum corresponds to a fixed point of attraction). The extremal value of the square ...