introduction: previous studies have raised the probably of cardiac manifestation in tramadol poisoning. however, conclusive information on electrocardiographic (ecg) abnormalities of tramadol overdose remains to be explained. therefore, the present study aimed to evaluate the epidemiology of ecg abnormalities in tramadol poisoned patients. methods: in a prospective cross-sectional study, all pa...

objectives: graft versus host disease (gvhd) is a life threatening reaction in the stem cell transplantation process. nowadays cyclosporine is the most commonly utilized agent for gvhd prophylaxis and it has a major role in successful transplantation. cyclosporine has been applied for many years in this field but it could be stated that currently no general consensus is available for its optima...

Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled with antiepileptic drugs suffer from their adverse events. Epileptic patients have different challenges in relation to the disease and its medicat...

Differentiating between complicating consequences of HIV infection and toxicities of drugs used in the management of HIV infection is challenging. However, the experience gained with combination antiretroviral (ARV) drugs has led to the recognition of several distinct adverse drug events. These include: • mitochondrial dysfunction (including lactic acidosis, hepatic toxicity, pancreatitis, and ...

background: adverse cutaneous drug reactions (acdrs) are the most commonly reported adverse drug events. the causative drugs and clinical patterns of acdrs are different in various populations. this study was conducted to identify the clinical patterns, causative drugs and reasons for drug administration in patients hospitalized due to acdr. materials and methods: this retrospective study was c...

adverse drug reaction (adr) is one of the most life threatening problems, and the economic burden of adr is considerable. the main objective of this study was to assess the attitude of the kerman health system staff, to evaluate their knowledge of the spontaneous reporting system and to identify the reasons for low reporting rate. in this descriptive study, a persian translated questioner was u...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

conclusions the best balance between detection rate of prostate cancer and infectious complications of biopsies achieved in twelve-core biopsy protocol. twelve-core biopsy enhances the rate of prostate cancer detection with minimum adverse effects. patients and materials transrectal ultrasonography (trus) guided biopsy was performed in 180 patients suspicious for prostate cancer due to either a...