Lenalidomide is a potent, novel thalidomide analog that has demonstrated promising clinical activity in patients with relapsed or refractory multiple myeloma (MM). It is a lead immunomodulatory drug currently approved by the U.S. Food and Drug Administration. Neutropenia, thrombocytopenia, and thromboembolic events are common adverse effects associated with lenalidomide therapy in patients with...

Proton pump inhibitors effectively treat gastroesophageal reflux disease, erosive esophagitis, duodenal ulcers, and pathologic hypersecretory conditions. Proton pump inhibitors cause few adverse effects with short-term use; however, long-term use has been scrutinized for appropriateness, drug-drug interactions, and the potential for adverse effects (e.g., hip fractures, cardiac events, iron def...

and are available from booksellers through the network of WHO sales agents. A list of these agents may be obtained by writing to the above address. (CIOMS) is a nongovernmental organization established jointly by the World Health Organization and UNESCO in 1949, with a mandate to collaborate with the United Nations and its specialized agencies. Its international membership, consisting of intern...

INTRODUCTION Surgical patients are exposed to multiple foreign substances in the perioperative period including drugs, blood products, or environmental antigens such as latex. Because any substance can produce an allergic or adverse reaction, clinicians must be ready to manage patients in this perioperative environment. The most life-threatening form of an allergic reaction is anaphylaxis, howe...

| August 2014 | 798 Finally, the authors detected a higher prevalence of more serious and life-threatening types of ACDR like Stevens Johnson and toxic epidermal necrolysis in their study. This finding is so important and may be due to the difference in type and potency of metabolic pathways in Iranian patients due to their ethnic groups, or it may be due to not including the above mentioned ri...

Adverse drug reactions are a common problem for patients and their physicians. About 6% to 10% of adverse drug reactions are allergic. Obtaining a detailed history is very important. Discontinuation of therapy with a suspect drug is the most helpful diagnostic modality. It is also the treatment of choice. Consultation with an allergist for individualized evaluation and recommendations may be be...

An adverse drug reaction (ADR) is an unwanted, undesirable effect of a medication that occurs during usual clinical use. Adverse drug reactions occur almost daily in health care institutions and can adversely affect a patient’s quality of life, often causing considerable morbidity and mortality. Much attention has been given to identifying the patient populations most at risk, the drugs most co...

Adverse drug reactions (ADRs) remain a challenge in modern healthcare, particularly given the increasing complexity of therapeutics, an ageing population and rising multimorbidity. This article summarises some of the key facts about ADRs and explores aspects relating to their prevention, diagnosis, reporting and management in current clinical practice.