To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The coating performed different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and continuous conical screen mill (Comil)) resulting dry-coated were compared. Ethenzamide (ETZ), which has low ...

Guaco (Mikania glomerata Sprengel) syrup is one of the most popular herbal medicines used to treat the symptoms of asthmatic bronchitis, cough and hoarseness. The coumarin 2H-1-benzopyran-2-one, is one of the major constituents of Guaco and contributes to its pharmacological effects. The pharmaceutical capsule form of dry extract of Guaco is recommended by the Brazilian Program of Medicinal Pla...

Liquid crystals offer many unique opportunities to study various phase transitions with continuous symmetry in the presence of quenched random disorder (QRD). The QRD arises from the presence of porous solids in the form of a random gel network. Experimental and theoretical work supports the view that for fixed (static) inclusions, quasi-long-range smectic order is destroyed for arbitrarily sma...

The current investigation was used to improve the rate of dissolution an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in stomach) by reducing water secretion and electrolyte intestine liquisolid tablets. Different formulations (liquisolid) were prepared using Avicel PH 102 as a carrier. Aerosil 200 coating material sodium starch glycolate disintegrant. Polyethylene gl...

Hydrophobic grade fumed silicas are generally used in tabletting as lubricants. They are also found to retard the release of pharmaceutical actives. This is because of their hydrophobic nature, which gives good cohesive and adhesive properties. considering this point it was thought that they could be used as dry coating agents for solid dosages forms. The model drug selected for this work was p...

A liquisolid orodispersible tablet of felodipine, a BCS Class II drug, was developed to improve drug dissolution and absorption through the buccal mucosa for management of hypertensive crisis. A 24 full-factorial design was applied to optimize felodipine liquisolid systems (FLSs) having acceptable flow properties and possessing enhanced drug dissolution rates. Four formulation variables; The li...

A high-resolution calorimetric study has been carried out on nanocolloidal dispersions of aerosils in the liquid crystal 4-n-pentylphenylthiol-4'-n-octyloxybenzoate (8S5) as a function of aerosil concentration and temperature spanning the smectic-C to nematic phases. Over this temperature range, this liquid crystal possesses two continuous XY phase transitions: a fluctuation-dominated nematic t...