The objective of the present work was to obtain pH independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisolid compacts were prepared using Transcutol HP as vehicle, Avicel PH102 as carrier, and Aerosil 200 as a coating material. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow pr...

The effect on the nematic to smectic-A transition in octylcyanobiphenyl (8CB) due to dispersions of hydrogen-bonded silica (aerosil) particles is characterized with high-resolution x-ray scattering. The particles form weak gels in 8CB creating a quenched disorder that replaces the transition with the growth of short-range smectic correlations. The correlations include thermal critical fluctuati...

Aim. To develop the content of adhesive composition, being one stages in developing transdermal therapeutic system with anti-inflammatory action. Materials and methods. Using organoleptic research methods, properties affecting process applying to base subsequently quality finished product were studied. Color, consistency homogeneity determined visually, features mass recorded. determine optimal...

Objective: The objective of the present study was to compare release effect Luliconazole from different polymeric (Hydrophilic and Hydrophobic) microsponges prepared using varying concentrations. best microsponge selected incorporated into gel (Natural synthetic) drug is determined compared with marketed formulation.
 Methods: Polymers such as EC, HPMC, Eudragit RSPO PVA emulsifier, solven...

The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical optimization technique. The formulations were prepared based on 3(2) factorial design, with polymer ratio (HPMC 100 KM: Xanthan gum) and the amount of aerosil, as two independe...

The purpose of this study is to develop a novel liquisolid technique to enhance the dissolution rate of poorly water soluble drug Carvedilol, a BCS class II drug, which is a β-blocker, by using different excipients. The main components of a liquisolid system are a non volatile solvent, carrier and coating materials and a disintegrant. Liquisolid system refers to the formulations that are formed...

High-resolution calorimetric studies have been made of the liquid crystal phase transitions for several dispersions of 70-Å-diam silica spheres ~aerosil! in octylcyanobiphenyl ~8CB! as a function of silica density rS . The excess specific heat peaks associated with the nematic-isotropic (N-I) and the nematic–smectic-A (N-SmA) transitions both exhibit shifts to lower temperatures, decreases in t...

It is important to achieve high strength, modulus of elasticity, good energy damping for lightweight armor materials. For this purpose, two or more similar different materials are combined at the macro level. In way, a new structure emerges that we call composite material. A in which properties components its become evident Research on production and mechanical composites meet needs developing ...