BACKGROUND E-cigarettes or electronic nicotine delivery systems (ENDS) are designed to deliver nicotine-containing aerosol via inhalation. Little is known about the health effects of flavoured ENDS aerosol when inhaled. METHODS Aerosol from ENDS was generated using a smoking machine. Various types of ENDS devices or a tank system prefilled with liquids of different flavours, nicotine carrier,...

Aerosols of a physiological salt solution and aqueous solutions of salbutamol, sodium cromoglicate, and dornase alfa were generated in a pneumatic nebulizer and analyzed in a system with controlled humidity of air as a carrier gas. Mass distribution of aerosol particles and yield of generation for pulse nebulization were measured. Pulsation of generation was realized with an attachment maintain...

With a few simple modifications, an aerosol mask was adapted to deliver high concentrations of oxygen. We compared the delivery of high concentrations of oxygen by this modified aerosol mask (MAM) with that of a nonrebreathing mask (NRM) in five normal volunteers and six patients with respiratory failure. Besides improved oxygenation, the MAM also permitted the following: humidification of the ...

Patients with obstructive lung disease often present with life-threatening respiratory failure, confounded by severe air-flow limitation, dynamic hyperinflation, intrinsic PEEP, reduced pulmonary compliance, hypercarbia, and hemodynamic instability. Inhaled bronchodilators play a vital role in the care of such patients and are one of the most widely prescribed medications in the critical care s...

Orally inhaled therapies are a cornerstone of lung health maintenance in CF. Topical application of drugs in the airways increases the efficacy and reduces the systemic exposure and toxicity of these agents. Most CF patients are treated with aerosolized therapies, and many take multiple inhaled drugs on a daily basis. Treatments for bronchodilation, inflammation, airway clearance and early or c...