The advantages of using isolated cells have led us to develop short-term cultures of hippocampal pyramidal cells, which retain many of the properties of cells in acute preparations and in particular the ability to generate afterhyperpolarizations after a train of action potentials. Using perforated-patch recordings, both medium and slow afterhyperpolarization currents (mI(AHP) and sI(AHP), resp...

The Ca(2+)-dependent slow afterhyperpolarization (AHP) is an important determinant of neuronal excitability. Although it is established that modest changes in extracellular pH (pH(o)) modulate the slow AHP, the relative contributions of changes in the priming Ca(2+) signal and intracellular pH (pH(i)) to this effect remain poorly defined. To gain a better understanding of the modulation of the ...

JMP® scripting language (JSL) can be used to implement the Analytic Hierarchy Process (AHP). AHP helps decisionmakers choose the best solution from several options and selection criteria. Thomas Saaty developed AHP as a decision-making method in the 1970s. AHP has broad applications in operations research, quality engineering, and design-for-six-sigma (DFSS) situations. AHP builds a hierarchy (...

Pyramidal neurons in the piriform cortex from olfactory-discrimination trained rats show enhanced intrinsic neuronal excitability that lasts for several days after learning. Such enhanced intrinsic excitability is mediated by long-term reduction in the post-burst after-hyperpolarization (AHP) which is generated by repetitive spike firing. AHP reduction is due to decreased conductance of a calci...

Selection of qualified persons suitable for different organization functions is a key success factor for an organization. The complexity and importance of the problem call for analytical methods rather than intuitive decisions. The personnel selection problem requires the application of multi-criteria decision making (MCDM) methods for robust recruitment. This paper has to objectives; first to ...

Activation of group I metabotropic glutamate receptors (mGluRs) leads to a concerted modulation of spike afterpotentials in guinea pig hippocampal neurons including a suppression of both medium and slow afterhyperpolarizations (AHPs). Suppression of AHPs may be long-lasting, in that it persists after washout of the agonist. Here, we show that persistent AHP suppression differs from short-term, ...

OBJECTIVES To determine the most common ocular causes and types of abnormal head position (AHP) and describe their clinical features. MATERIALS AND METHODS Patients with AHP who had been followed in the strabismus unit were retrospectively reviewed. Demographic features and orthoptic characteristics were recorded. RESULTS A total of 163 patients including 61 women (37.4%) and 102 men (62.6%...

CA1 pyramidal neurons from animals that have acquired a hippocampus-dependent task show a reduced slow post-burst afterhyperpolarization (slow AHP). To understand the functional significance of this change, we examined and characterized the slow AHP activated by different patterns of synaptic stimuli and its impact on postsynaptic signal integration. Whole cell current-clamp recordings were per...

Previous studies have revealed a new form of activity-dependent modulation of the afterhyperpolarization (AHP) in tactile (T) neurons of the leech Hirudo medicinalis. The firing of T cells is characterized by an AHP, which is mainly due to the activity of the Na+/K+ ATPase. Low-frequency repetitive stimulation of T neurons leads to a robust increment of the AHP amplitude, which is correlated wi...

In this study the integration of an absorption heat pump (AHP) with the concentration section of an industrial pulp and paper process is investigated using pinch technology. The optimum design of the proposed water-lithium bromide AHP is then achieved by minimizing the total annual cost. A comprehensive optimization is carried out by relaxation of all stream pressure drops as well as heat excha...