The aim of this study was to explore the expression of PI3K, AKT, and P-AKT, and to investigate the role of PI3K/AKT signaling pathway in thin endometrium. We included 40 women treated in affiliated Shenzhen Nanshan People's Hospital of Guangdong Medical University for endometrial conditions between August 2013 and January 2015, 20 with a normal endometrium, and 20 with thin endometrium. The ex...

Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent studies by our group have found accumulation of activated Akt in the nucleus, s...

Abstract Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol a triterpenoid isolated from Ganoderma lucidum known to have various biological functions, including antibacterial effects. However, anti-cancer effects mechanism action lucidadiol in malignant melanoma are unknown. In this study, significantly reduced B16 cell viability dose- time-dependent manner. addition, in...

Objective: Despite advances in treatment approaches, metastatic castration-resistant prostate cancer (mCRPC) remains a clinical challenge to treat. Cabazitaxel (Cab), third-line chemotherapy option for mCRPC, exhibits limited efficiency due the activation of different signaling pathways associated with drug resistance. The PI3K/AKT/mTOR has led mCRPC progression, and long-term acquired Cab Howe...

This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), (Bcl-2), caspase 3, mammalian target rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), kinase B (AKT) gene expr...

The browning of white fat has become a hot topic as it could help to lose weight and improve metabolic health. Therefore, this study aims explore the in vivo or thermogenesis effect 6-gingerol (6G), natural bioactive compound ginger, clarify underlying mechanism. results showed that 6G limited gain, improved cold tolerance, increased energy expenditure high-fat diet-induced obese mice. Moreover...

Yang He Decoction (YHD), a classical Chinese medicine prescription, is used to treat bone and joint diseases. However, there are few mechanism studies for YHD on the use of tuberculosis (BT) corresponding action YHD. In present study, chemical ingredients targets were revealed by network pharmacology method, an ingredient–target–disease was visualized analyzed. Then, gene ontology enrichment an...

Purpose: To investigate the influence of suppressor cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
 Methods: Sprague-Dawley (SD) were randomly divided into CC group and control group, then rat model was constructed. The expression SOCS3 in tissues determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) used to examine tis...

We recently reported translocation and activation of Akt in cardiac mitochondria. This study was to determine whether activation of Akt in mitochondria could inhibit apoptosis of cardiac muscle cells. Insulin stimulation induced translocation of phosphorylated Akt to the mitochondria in primary cardiomyocytes. A mitochondria-targeted constitutively active Akt was overexpressed via adenoviral ve...