نتایج جستجو برای: akt
تعداد نتایج: 40794 فیلتر نتایج به سال:
ارزیابی اثرات کاهش بیان ژن tnf-α بر مقاومت به انسولین القاء شده با پالمیتات در سلول های عضلانی c۲c۱۲
مقدمه: مقاومت به انسولین نقص اصلی در دیابت نوع 2 و چاقی می باشد. طی این اختلال تجمع لیپید همراه با افزایش بیان tnf-α در عضله رخ میدهد. هدف پژوهش حاضر ارزیابی اثرات کاهش بیان tnf-α بر مولکولهای کلیدی مسیر پیام رسانی انسولین (irs-1 و akt) و مقاومت به انسولین در رده ی سلولهای عضلانی c2c12 در حضور و عدم حضور پالمیتات بود. مواد و روشها: برای کاهش بیانtnf-α ، سلولهای c2...
parkinson's disease (pd) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring alzheimer's disease (ad). currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of pd. out of several factors contributing to pd prognosis, the role of p38 mapks (mitog...
objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...
objective(s):higher cellular reactive oxygen species (ros) levels is important in reducing cellular energy charge (ec) by increasing the levels of key metabolic protein, and nitrosative modifications, and have been shown to damage the cardiac tissue of diabetic mice. however, the relation between energy production and heart function is unclear. materials and methods:streptozotocin (stz, 150 mg/...
Purpose: To investigate the effect of Qibai Pingfei capsules (QBPF) medicated serum on apoptosis rat pulmonary artery smooth muscle cells (PASMC) in hypoxic rats, and to determine relationship between that PI3K/Akt/mitochondrial pathway.Methods: Rat PASMCs were isolated, cultured, optimal time concentration QBPF determined by CCK-8 method. Hypoxic rats treated with QBPF, + LY294002, or SC79. Ap...
Abstract Background Preeclampsia (PE) is a pregnancy related disease that affects about 5% of pregnancies. Death receptor 3 (DR3) expression significantly elevated in both placental tissue and plasma PE patients. However, whether DR3 was involved trophoblasts pathogenesis are not well elucidated. Objective Our research designed to illustrate the biological roles trophoblasts, as explain its rel...
Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, involvement phosphatase tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway process.
 Methods: Human cell line SV-HUC-1 human T24 were randomly assigned to blank control group groups. Protein expression levels apoptosis-related factors (Bcl-2, Bax, caspase-3] ...
Background/aim Previous studies have shown that the sandalwood oil constituent α-santalol inhibits growth of cultured human prostate cancer cells in vitro and PC-3 xenografts. Along with from our laboratory, it is well established targets phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT serine/ threonine kinase 1 (AKT) pathway to induce apoptosis but its growth-suppressive effects not been fu...
مقدمه و هدف: علیرغم مشاهدات بالینی فراوان مبنی بر اثرات مفید هیپوکسی متناوب، تا به حال مکانیسم اثر آن بر روی آنژیوژنز بافت قلب بررسی نشده است. بنابراین، هدف از تحقیق حاضر بررسی تاثیر تمرین هوازی و هیپوکسی متناوب بر بیان پروتئینهای مرتبط با آنژیوژنز در بافت قلبی موشهای نر نژاد ویستار بود. روششناسی: تعداد 40 رأس موش صحرایی در محدوده وزنی 20±220 گرم، به طور تصادفی در 4 گروه 10تایی: کنترل سالم...
Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...
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