BACKGROUND Vancomycin-resistant enterococci are pathogenic bacteria that attenuate antibiotic sensitivity by producing peptidoglycan precursors that terminate in D-Ala-D-lactate rather than D-Ala-D-Ala. A key enzyme in effecting antibiotic resistance is the metallodipeptidase VanX, which reduces the cellular pool of the D-Ala-D-Ala dipeptide. RESULTS We constructed eleven mutants, using the r...

The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines high prevalence late complications diabetes, including diabetic polyneuropathy (DPN), most common type polyneuropathy. Oxidative stress is considered main reason for cellular pathology development mellitus, which use antioxidants DPN treatment. Alpha-lipoic acid (ALA), a natural fat-solub...

This research determines the Acceptable Level of Acceptance (ALA) based on countries with active Nuclear Power Plant (NPP). The ALA is a particular value public acceptance NPP, indicating support and participation in program. If level lower than ALA, then probability resistance against program relatively high would harm NPP. There no correlation between number populations. uses four categories ...