BACKGROUND Teucrium polium is an analgesic, antidiabetic and antilipeidemic herbal medicament. The aim of this survey was to evaluate the effect of aqueous extract T. polium on liver enzymes linked to liver dysfunction, serum lipids and glucose, in diabetic male rats. METHODS A total of 20 Sprague-Dawly male rats became diabetic by intraperitoneal injection of streptozotocin (60 mg/kg). the a...

conclusions these results indicated that chronic administration of mdma affects liver as well as lipoprotein profile in male rats. the exact mechanism of action needs further investigation. background ecstasy is used to improve mood and cordiality; however, based on some reports, it is neurotoxic to human users. objectives because of the euphoria induced by mdma (3,4-methylenedioxymethamphetami...

Aspartate and glutamate react instantaneously with the pyridoxal form of the pig heart glutamic aspartic transaminase (1) to yield the corresponding keto acid, converting the enzymebound pyridoxal phosphate to bound pyridoxamine phosphate (2). Other amino acids such as methionine sulfoxide, methionine sulfone, and alanine react much more slowly with the enzyme, but the reaction itself appears t...

This preliminary study was undertaken to investigate some biochemical and histological effects of consumption of Talinum triangulare (L.) Juss – supplemented diet in hepatotoxic rats in which liver damage was induced with paracetamol. Thirty female rats were divided into six groups of five rats per group for control, hepatotoxic and non-hepatotoxic groups and were fed 5% or 10% T. triangulare-s...

Objective: To explore and summarize the effect of sirolimus on ischemic-type biliary lesions (ITBL) after liver transplantation. Methods: A retrospective study was carried out on 52 patients using sirolimus for biliary complications after liver transplantation from 2004 to 2016 in our hospital. Serum alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin, glutamyl endopeptida...

Among the mechanisms which have been considered as possible descriptions of the molecular events underlying hormone action, one which has attracted increasing attention among contemporary biochemists is the proposal that control of the biosynthesis of specific enzymes may be an important factor (see, e.g., ref. 1). The plethora of enzyme activities which are found to increase or decrease in res...

The major aim of this work was to investigate how alcohol-induced oxidative stress in combined chemotherapy changes the metabolic function of the liver in experimental animals. This research was conducted to establish how bromocriptine, haloperidol and azithromycin, applied to the experimental model, affected the antioxidative status of the liver. The following parameters were determined: reduc...

The activities of aspartate and alanine transaminase, serine dehydratase, arginase, glutamate dehydrogenase, adenylate deaminase and glutamine synthetase were determined in the stomach and small intestine of developing rats. Despite the common embryonic origin of the intestine and stomach, their enzymes showed quite different activity levels and patterns of development, depending on their roles...

The existence of a glutamic acid racemase activity in Lactobacillus arabinosus has been reported by Narrod and Wood (1) and by Ayengar and Roberts (2). As has been pointed out by Meister (3) these observations with dried cell preparations would not exclude a mechanism for glutamic acid racemization in which alanine racemase is coupled with n-glutamic acid-nalanine transaminase and n-glutamic ac...

The aim of the present study was to investigate the toxicological effects of moxifloxacin in mice to determine the toxicological implications. Forty mice of both sexes were divided into four groups of 10 mice each, designated as A, B, C and D. Group A served as the control and received 2 ml of distilled water, while Groups B, C and D were orally administered 12.5, 25 and 50 mg/kg body weight of...