Purpose: Albendazole is a poorly soluble drug which limits its oral bioavailability. The study was focussed to enhance the solubility by in-situ micronization. Methods: Albendazole microcrystals were prepared by solvent change method using gum karaya and hupu gum as stabilizing agents and the effect of each stabilizer on the prepared microcrystals were studied. FT-IR, DSC, XRD and SEM analysis ...

Single, small, enhancing lesions that often resolve spontaneously are frequent findings on CTs of Indian patients with seizures. Based on ELISA and biopsy data, the majority of these lesions are probably cysticercosis. To determine if these patients should be treated with albendazole, we performed a double-blind, randomized, placebo-controlled study involving 75 patients with seizures and the a...

The objective of this study was to improve the solubility of albendazole and optimize the preparation of an oral nanoparticle formulation, using β-cyclodextrin (βCD) and chitosan-tripolyphosphate (TPP) nanoparticles. The solubility of albendazole in buffers, surfactants, and various concentrations of acetic acid solution was investigated. To determine drug loading, the cytotoxic effects of the ...

Albendazole is an anti-helmintic or anti-worm medication. Due to its water insolubility, it shows poor absorption in GIT as well low bioavailability and produces therapeutic effect. In this study, various hydrotropic agents are used enhance the solubility of Albendazole. Addition 100mg 1M Solution agent like Sodium benzoate, acetate, citrate, salicylate & urea separately absorbance each sol...

A comparative efficacy of piperazine, albendazole and ivermectin against natural infection of Toxocara vitulorum based on faecal egg count in calves was studied. Early recovery was found with piperazine than with either albendazole or ivermectin. However, all the three drugs were effective against ascariasis in cattle calves.

Drug-induced dystonic reactions are a common presentation to the Pediatric Emergency Department frequently with antiemetics, antidepressants, dopamineblocking agents and antipyschotics. We report a case of generalized form of dystonia after taking albendazole and cetirizine. There is only one case with albendazole induced and two cases with cetirizine induced dystonia in the literature.

The anthelmintic activity of the Imethanolic extract of the root bark of Carissa carandas was evaluated on adult Indian earthworm (Pheretima posthuma) using albendazole as a reference standard. The extract caused paralysis followed by the death of worm at the tested dose level. The extract at the highest tested concentration has anthelmintic activity comparable with that of standard drug albend...

BACKGROUND Neglected tropical diseases are co-endemic in many areas of the world, including sub Saharan Africa. Currently lymphatic filariasis (albendazole/ivermectin) and trachoma (azithromycin) are treated separately. Consequently, financial and logistical benefit can be gained from integration of preventive chemotherapy programs in such areas. METHODOLOGY/FINDINGS 4 villages in two co-ende...

The benzimidazole anthelmintic drug albendazole becomes metabolized to chiral sulfoxide, sulfone, 2-aminosulfone, and other metabolites. High-performance liquid chromatography with UV absorbance fluorescence detection, mass spectrometry, electrokinetic were used analyze metabolites in extracts of western lowland gorilla (Gorilla gorilla) plasma patients alveolar echinococcosis the data are comp...

The purpose of the research is to develop and test new dosage forms against bothriocephalosis cyprinids. Materials methods . study was performed in experimental therapy laboratory VNIIP – FSC VIEV, on a cage fish farm Cherepetsky Rybkhoz JSC (Suvorov, Tula Region). A formulation developed for two micronized albendazole praziquantel prevent treat cestodosis fish, namely, praziquantel. For experi...