Objective: The study aims to evaluate the anthelmintic activity of aqueous extract Ardisia colorata Roxb. leaves (AQEAC) using adult earthworms (Pheretima posthuman).
 Methods: total 24 were divided into four groups, with six worms in each group (n=6). AQEAC at two different doses (25 mg/ml and 50 mg/ml) was evaluated by assessing time paralysis (min) death earthworms. Albendazole used as ...

The present investigation was aimed at studying the effect of incubation period, media, vitamins and solvents on biotransformation of albendazole by Cunninghamella blakesleeana. The transformation was evaluated and identified by high performance liquid chromatography (HPLC) and the structures of the transformed products were assigned by liquid chromatography-tandem mass spectrometry (LC/MS/MS) ...

We examined the therapeutic effects of albendazole compared to metronidazole in 120 patients with giardiasis in Hamdan. Patients were randomized to receive albendazole (400 mg, once daily for 5 days) or metronidazole (250 mg, 3 times a day for 5 days). Demographic data of the patients, results of stool examination for Giardia trophozoites before and after treatment, and drug side-effects were r...

The study aim to develop simple, sensitive, rapid, accurate and precise spectrophotometric method for estimation on albendazole and ivermectin in tablet dosage forms. Pure drug sample of albendazole and ivermectin were dissolved in a mixture of methanol and 1 N HCl (70:30). Two wavelengths selected for formation and solving the simultaneous equations were 248.8 nm for albendazole and 314.4 nm f...

BACKGROUND The currently used anthelmintic drugs, in single oral application, have low efficacy against Trichuris trichiura infection, and hence novel anthelmintic drugs are needed. Nitazoxanide has been suggested as potential drug candidate. METHODOLOGY The efficacy and safety of a single oral dose of nitazoxanide (1,000 mg), or albendazole (400 mg), and a nitazoxanide-albendazole combinatio...

The low bioavailability of albendazole affects the therapeutic response in patients with echinococcosis. Cimetidine co-administration is reported to improve bioavailability. To analyze the assumed dose-dependent bioavailability of albendazole, we administered 5 to 30 mg/kg albendazole to 6 male volunteers in a randomized cross-over study. To assess the effect of cimetidine (10 mg/kg twice daily...

Most authors believe that the best treatment for pulmonary hydatid disease is surgical evacuation. Although albendazole has been used prophylactically before surgery, there are many reports about increased incidence of the rupture of cyst after albendazole therapy, which can cause some complications. In this case report we present a patient with bilateral pulmonary hydatid cyst that was rupture...

Cutaneous larva migrans (CLM) is a skin disorder in the form of serpiginous spreading with erythematous and papule as reaction to invasion hookworm. Apart from infection symptoms, helminthic infections tend most frequently involve respiratory, gastrointestinal, neurological, eye. We report case 21-year-old male who came papules linear tracks entire body that felt itchy, especially on abdomen at...

results in this case, the protoscolicidal effect of artemether and its combinations was significantly (p < 0.05) higher than other groups; the maximum protoscolicidal effect was found with 200 μg/ml of artemether after 4 days whereas albendazole killed protoscoleces on the 7th day post-incubation. surprisingly, the incubation of protoscoleces with artemisinine exhibited promising results, as on...