BACKGROUND Cancer is a severe threat to the human society. In the scientific community worldwide cancer remains a big challenge as there are no remedies as of now. Cancer is quite complicated as it involves multiple signalling pathways and it may be caused by genetic disorders. Various natural products and synthetic molecules have been designed to prevent cell proliferation. Peptide-based antic...

Serum albumins are the most abundant carrier protein in the circulatory system and are involved in the transportation and distribution of exogenous and endogenous materials in blood [1], including nutrients and drugs, mostly by the formation of noncovalent complexes at binding sites [2]. The absorption, distribution, metabolism, and excretion properties as well as the stability and toxicity of ...

This research aimed to determine the biofunctional properties of wheat flour (WF) protein fractions and modifications antioxidant, anti-α-amylase anti-angiotensin-I converting enzyme (ACE) activities induced by action digestive endopeptidases in vitro. A molecular characterization most abundant fractions, i.e., albumins, glutelins-1, glutelins-2 prolamins, showed that low- high-MW polypeptides ...

BACKGROUND Monitoring of biochemical markers of inflammation in acute mediastinitis (AM) can be useful in the modification of treatment. This study was a retrospective evaluation of selected biochemical parameters with negative impact on the prognosis in surgically treated patients. MATERIAL/METHODS There were 44 consecutive patients treated surgically due to AM of differentiated etiology. Se...

Inflammatory bowel disease (IBD) is an inflammatory disease of unclear etiopathogenesis and challenging diagnosis, frequently complicated by anemia and malnutrition. C-reactive protein (CRP) remains the only biochemical marker of clinical relevance. The aim of this study was to test hypothesis that transferrin, coinfluenced by inflammation, malnutrition, anemia, and oxidative stress, may better...

Nicotinic receptors containing alpha7 subunits are ligand-gated ion channels widely distributed in the nervous system; they influence a diverse array of events because of their high relative calcium permeability. We show here that nicotine-induced whole-cell responses generated by such receptors can be dramatically potentiated in a rapidly reversible manner by some but not all albumins. The pot...

The levels of biochemical parameters in the blood serum of Simmental service bulls were studied. The research was conducted on twelve bulls at the age of four to seven. The blood was taken on four occasions by needle biopsy from the vena jugularis externa. In the samples of blood serum, the activities were specified of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glut...

Serum Anti Ular Bisa (SABU) is the only snake antivenom produced locally in Indonesia; however, its effectiveness has not been rigorously evaluated. This study aimed to assess the protein composition and neutralization efficacy of SABU. SDS polyacrylamide gel electrophoresis, size-exclusion liquid chromatography and shotgun proteomics revealed that SABU consists of F(ab')2 but a significant amo...

The magnitude of the inhibitory actiyity in MRP from ct,-casein and the three aldoses correlated with the reactivity of the aldoses vrith pruteins. The MRP from x.-casein and albumins inhibited GTF-I and did not affect GTF-S, -'hile their origina] proteins stimulated GTF-I specifically, These results suggest that the inhibitory activity of these MRP may be related to the GTF-I st;mulating prepe...