CSN1S1is one of the major genes encoding milk proteins of mammals. In this study we determined allele frequencies of CSN1S1-5` flanking region as well as exon 17 variants and their effects on milk traits in three indigenous cattle breeds Mazandarani, Golpaygani (Bos indicus) and Sarabi (Bos taurus) and Holstein cattle in Iran. CSN1S1*B variant was nearly fixed in Holstein but ranged from 0.40 t...

background: human leukocyte antigen-g (hla-g) is a non-classical class i molecule highly expressed by extravillous cytotrophoblast cells. due to a single base pair deletion, its function can be compensated by other isoforms. investigating the frequency of null allele in recurrent miscarriage (rm) subjects could be useful in understanding the relationship between frequency of this allele and rm ...

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...

angiotensin i-converting enzyme (ace) gene polymorphism; genotype dd or d allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (dn). we examined the frequency of ace gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in tehran, iran. dna was extracted from the white blood cells and the i/d polymorphism of the ...

Background: HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to in-hibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace th...

to determine the protein polymorphism of ovine transferrin association with carcass economic traits in makoei, blood samples of 576 (male and female) lambs with two types of venoject (edta anticoagulant containing and non-anticoagulant containing). plasma and serum were then separated and kept in the central laboratory of animal science depaartment in karaj at -20°c. the research was conducted ...

background: hla-g gene contains 15 alleles including a null allele, hla-g*0105n. previous studies have shown that hla-g*0105n does not encode the complete hla-g1 or hla-g5 isoforms but encodes a functional hla-g protein with the ability to in-hibit nk cell cytolysis. thus, although the biological functions of hla-g1 and hla-g5 proteins are abrogated, other isoforms such as hla-g2 can replace th...

in this study we estimated the allele and genotype frequencies of scd1 and dgat1 gene polymorphism. the analysis was conducted on 408 holstein cows from five dairy herds in isfahan province. genotypes were identified using pcr-rflp technique. two genetic variants (a and v) of the scd1 gene were observed in this experiment. the frequency of a-allele ranged from 0.49 to 0.66, while frequency of v...

background: major histocompatibility complex (mhc) in chicken has profound influence on resistance/susceptibility to disease, and production and reproduction traits. microsatellite marker lei0258 is a genetic indicator for mhc haplotypes. recognizing diversity of mhc haplotypes in selectively bred populations will be helpful for selecting population resistant to disease and development of effec...