Pollen allergies have long been a major pandemic health problem for human. However, the evolutionary events and biological function of pollen allergens in plants remain largely unknown. Here, we report the genome-wide prediction of pollen allergens and their biological function in the dicotyledonous model plant Arabidopsis (Arabidopsis thaliana) and the monocotyledonous model plant rice (Oryza ...

The most important house dust mites are Dermatophagoides pteronyssinus and in drier areas D. farinae. In subtropical and tropical regions the glycyphagid mite Blomia tropicalis is a major source of allergen, which co-exists with D. pteronyssinus. The group 1 and 2 allergens of Dermatophagoides mites are clearly major specificities and it is likely that these allergens could be the basis of new ...

BACKGROUND Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sens...

Epicutaneous patch testing is a well-established diagnostic method for identifying substances that may cause Allergic Contact Dermatitis (ACD), common skin condition caused by exposure to environmental allergens. While the test remains gold standard allergens, it prone observer bias and consumes valuable human resources. Deep learning models can be employed address this challenge. In study, we ...

The cockroach represents one of the most common sources of indoor allergens worldwide, and 40%-60% of patients with asthma in urban and inner-city areas possess IgE antibodies to cockroach allergens. In Korean homes, four cockroach species have been found, of which the most commonly encountered is the German cockroach. The pathogenic mechanism underlying the association between cockroach allerg...

Allergens from scales and cuticles of abdomen and wing of silk moth, Bombyx mori, causatives of allergic rhinitis have been subjected to solubilization with SDS (2%), urea (8M) and guanidine hydrochloride (6M). Allergens (70%) were extracted and all the solvent extracts contained an approx similar complement of allergens. Allergen composition of abdomen and wing scales differ from one another a...

Background: Various environmental factors can induce or exaggerate hand eczema. Objective: Evaluation of patch test results in hand eczema patients. Patients and Methods: In this descriptive study 100 patients with hand eczema referred to Loghman Hakim and Booali Hospital in Tehran underwent patch testing with 23 allergens obtained from Hermal company. Results: 240 positive reactions observed i...

PURPOSE This study evaluates offending allergens in patients with allergic rhinitis (AR) according to age that establish a minimal panel for skin prick test (SPT) allergens required to identify if a patient is sensitized. METHODS We retrospectively analyzed SPT results according to age to determine the minimum test battery panel necessary to screen at least 93%-95% of AR patients. Allergic sk...

Summary Background and Objectives. Stimulating the immune system by exposure to various allergens to produce specific IgE has a significant role in the pathogenesis of atopic dermatitis. Identifying disease-causing allergens, prevention of exposure to those allergens, and immunotherapy will play an important role in the treatment of Atopic Disease. The purpose of this study was to determine the...

“broussonetia papyrifera” (chinese mulberry) pollen is an important source of allergens in regions surrounding shanghai, china. to identify and purify major allergens from “b. papyrifera” pollen that reacted with serum antibodies from sensitized patients, “b. papyrifera” pollen was defatted, dried, and extracted proteins were separated using sp cationic exchange or q anionic exchange columns. s...