BACKGROUND Oxaliplatin, an important chemotherapy drug for advanced colorectal cancer, often induces peripheral neuropathy, especially cold allodynia. Our previous study showed that bee venom acupuncture (BVA), which has been traditionally used in Korea to treat various pain symptoms, potently relieves oxaliplatin-induced cold allodynia in rats. However, the mechanism for this anti-allodynic ef...

We have assessed the effects of intraplantar local anaesthetics (bupivacaine and lignocaine) on carrageenan-induced oedema, mechanical allodynia and spinal c-fos protein expression. Mechanical allodynia was evaluated using the vocalization threshold to paw pressure (VTPP) every 30 min until 60, 180 or 240 min after administration of carrageenan. Peripheral oedema, mechanical allodynia and spina...

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal horn, are crucial for tactile allodynia after nerve injury. Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microgli...

Abstract Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate association with pressure. Methods IIH:WT a randomised controlled parallel group multicentre trial United Kingdom investigating weight management methods IIH. Participants active IIH (evidenced by papilloedema) body mass index (BMI) ≥35 kg/m...

Altered receptive fields and sensory modalities of rat VPL thalamic neurons during spinal strychnine-induced allodynia. J. Neurophysiol. 78: 2296-2308, 1997. Allodynia is an unpleasant sequela of neural injury or neuropathy that is characterized by the inappropriate perception of light tactile stimuli as pain. This condition may be modeled experimentally in animals by the intrathecal (i.t.) adm...

Oxaliplatin (OXL) is a platinum-based antineoplastic drug widely used for treating colorectal cancer which induces peripheral neuropathy as dose-limiting toxicity. We assess the neuroprotective effects of losartan (LOS) and donepezil (DPZ) on OXL-induced in rats. Forty Sprague-Dawley rats were divided into four groups; control (vehicle-treated), OXL (2.4 mg/kg/d; intraperitoneal), OXL+LOS (100 ...

objective: vanillosmopsis arborea baker (asteraceae) has high economic value from chapada to araripe and its bark essential oil is a potential source of alpha-bisabolol. the present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of v. arborea baker (eova) in mice. materials and methods: the antinociceptive activity was assessed using the capsaicin,...