نتایج جستجو برای: allopregnanolone

تعداد نتایج: 513  

Journal: :International Journal of Molecular Sciences 2020

Journal: :Hormone Molecular Biology and Clinical Investigation 2016

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Kazuhiro Tokuda Yukitoshi Izumi Charles F Zorumski

Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase...

Journal: :Human brain mapping 2014
Rebecca K Sripada Robert C Welsh Christine E Marx Israel Liberzon

The neurosteroids allopregnanolone and dehydroepiandrosterone (DHEA) are integral components of the stress response and exert positive modulatory effects on emotion in both human and animal studies. Although these antidepressant and anxiolytic effects have been well established, to date, little research has examined their neural correlates, and no research has been conducted into the effects of...

Journal: :Molecular and cellular endocrinology 2005
Xue-Ying He Jerzy Wegiel Ying-Zi Yang Raju Pullarkat Horst Schulz Song-Yu Yang

The steroids allopregnanolone and allotetrahydrodeoxycorticosterone (3alpha,5alpha-THDOC) are positive allosteric modulators of GABA(A) receptors, generated by the reduction of 5alpha-dihydroprogesterone (5alpha-DHP) and 5alpha-DHDOC, respectively, under the catalysis of human type 3 3alpha-hydroxysteroid dehydrogenase (HSD). However, brain enzymes catalyzing the conversion of such tetrahydrost...

Journal: :Fertility and sterility 2003
Alessandro D Genazzani Massimo Stomati Francesca Bernardi Matteo Pieri Lucio Rovati Andrea R Genazzani

OBJECTIVE To evaluate the effects of a low-dose DHEA supplementation on hormonal parameters in early and late postmenopausal women. DESIGN Prospective case study. SETTING Postmenopausal women in a clinical research environment. PATIENT(S) Twenty postmenopausal women were divided in two groups according to age (50-55 and 60-65 years). INTERVENTION(S) All patients underwent hormonal evalu...

Journal: :Progress in brain research 2009
Iqbal Sayeed Donald G Stein

The search for a "magic bullet" drug targeting a single receptor for the treatment of stroke or traumatic brain injury (TBI) has failed thus far for a variety of reasons. The pathophysiology of ischemic brain injury and TBI involves a number of mechanisms leading to neuronal injury, including excitotoxicity, free radical damage, inflammation, necrosis, and apoptosis. Brain injury also triggers ...

Journal: :The Journal of Clinical Endocrinology & Metabolism 2002

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