نتایج جستجو برای: allopregnanolone

تعداد نتایج: 513  

2006
Şahruh Türkmen Sahruh Turkmen

...................................................................6 LIST OF ORIGINAL PAPERS ............................................7 ABBREVIATIONS ...........................................................8

2014
Pierrick Poisbeau Anne Florence Keller Maya Aouad Nisrine Kamoun Ghislaine Groyer Michael Schumacher

A growing number of studies indicate that 3-alpha reduced neurosteroids are remarkable analgesics in various pain states. This is the case for allopregnanolone (AP), one of the most potent endogenous positive allosteric modulators of GABAA receptor function. From the pioneering work of Hans Selye, who described the sedative properties of steroids, synthetic compounds resembling the progesterone...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Paula J Brunton Marcio V Donadio Song T Yao Mike Greenwood Jonathan R Seckl David Murphy John A Russell

Maternal social stress during late pregnancy programs hypothalamo-pituitary-adrenal (HPA) axis hyper-responsiveness to stressors, such that adult prenatally stressed (PNS) offspring display exaggerated HPA axis responses to a physical stressor (systemic interleukin-1β; IL-1β) in adulthood, compared with controls. IL-1β acts via a noradrenergic relay from the nucleus tractus solitarii (NTS) to c...

Journal: :Reproduction 2016
Erin L Legacki C J Corbin B A Ball M Wynn S Loux S D Stanley A J Conley

Mammalian pregnancies need progestogenic support and birth requires progestin withdrawal. The absence of progesterone in pregnant mares, and the progestogenic bioactivity of 5α-dihydroprogesterone (DHP), led us to reexamine progestin withdrawal at foaling. Systemic pregnane concentrations (DHP, allopregnanolone, pregnenolone, 5α-pregnane-3β, 20α-diol (3β,20αDHP), 20α-hydroxy-5α-dihydroprogester...

2009
Cristin D. Davidson Nafeeza F. Ali Matthew C. Micsenyi Gloria Stephney Sophie Renault Kostantin Dobrenis Daniel S. Ory Marie T. Vanier Steven U. Walkley

BACKGROUND Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused most commonly by a defect in the NPC1 protein and characterized by widespread intracellular accumulation of unesterified cholesterol and glycosphingolipids (GSLs). While current treatment therapies are limited, a few drugs tested in Npc1(-/-) mice have shown partial benefit. During a combination treatment ...

Journal: :The Journal of pharmacology and experimental therapeutics 2011
Damien E Earl Elizabeth I Tietz

Benzodiazepines (BDZs) depress neuronal excitability via positive allosteric modulation of inhibitory GABA(A) receptors (GABA(A)R). BDZs and other positive GABA(A)R modulators, including barbiturates, ethanol, and neurosteroids, can also inhibit L-type voltage-gated calcium channels (L-VGCCs), which could contribute to reduced neuronal excitability. Because neuronal L-VGCC function is up-regula...

Journal: :The Journal of pharmacology and experimental therapeutics 2013
Xin Wu Omkaram Gangisetty Chase Matthew Carver Doodipala Samba Reddy

The ovarian cycle affects susceptibility to behavioral and neurologic conditions. The molecular mechanisms underlying these changes are poorly understood. Deficits in cyclical fluctuations in steroid hormones and receptor plasticity play a central role in physiologic and pathophysiologic menstrual conditions. It has been suggested that synaptic GABA(A) receptors mediate phasic inhibition in the...

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