نتایج جستجو برای: allopregnanolone

تعداد نتایج: 513  

Journal: :The Journal of pharmacology and experimental therapeutics 2004
D S Reddy D C Castaneda B W O'Malley M A Rogawski

Many of the biological actions of progesterone are mediated through the progesterone receptor (PR), a nuclear transcription factor. Progesterone is well recognized to protect against seizures in animal models. Although this activity has been attributed to the progesterone metabolite allopregnanolone, a GABAA receptor-modulating neurosteroid with anticonvulsant properties, PRs could also play a ...

Journal: :Epilepsia 2013
Michael A Rogawski Carlos M Loya Kiran Reddy Dorota Zolkowska Christoph Lossin

Benzodiazepines are the current first-line standard-of-care treatment for status epilepticus but fail to terminate seizures in about one third of cases. Synaptic GABAA receptors, which mediate phasic inhibition in central circuits, are the molecular target of benzodiazepines. As status epilepticus progresses, these receptors are internalized and become functionally inactivated, conferring benzo...

2012
Graziano Pinna

Generalized anxiety, panic, and posttraumatic stress disorder (PTSD) are debilitating conditions, which have an incidence of one in ten persons in the general population and epidemiological studies also report that these disorders often occur with depression (1-3). Anxiolytic benzodiazepines, including diazepam and alprazolam, remain the best and most used treatments for these conditions (4-7)....

Journal: :Psychological medicine 2002
Bobby Heydari Jean-Michel Le Mellédo

BACKGROUND Animal studies have shown that neuroactive steroids modulate the activity of the gamma-aminobutyric acid type A/benzodiazepine receptor complex and that these steroids display anxiolytic or anxiogenic activity depending on their positive (e.g. allopregnanolone) or negative allosteric modulation (e.g. dehydroepiandrosterone sulphate) of this receptor. This study compared plasma levels...

Journal: :Journal of neuroscience research 2005
Iram Ahmad Silvia Lope-Piedrafita Xiaoning Bi Chad Hicks Yueqin Yao Clara Yu Elizabeth Chaitkin Christine M Howison Lyndon Weberg Theodore P Trouard Robert P Erickson

Niemann-Pick C disease (NPC) is an irreversible neurodegenerative disorder without current treatment. It is thought to result from deficient intracellular cholesterol and/or ganglioside trafficking. We have investigated the effects of allopregnanolone treatments on survival, weight loss, motor function, magnetic resonance imaging (MRI), and neuropathology in the mouse model of NPC (Npc1(-/-) mi...

Journal: :Current Opinion in Endocrine and Metabolic Research 2022

Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner to enhance the function of GABAA receptor (GABAAR), major inhibitory mammalian central nervous system (CNS). Consequently, allopregnanolone elicits anxiolytic, antidepressant, anticonvulsant, analgesic and sedative effects. Endogenous influences neural inhibition behaviour, with perturbed levels implicated de...

Journal: :Molecular pharmacology 2006
Wenjun Li Douglas F Covey Juha-Matti Alakoskela Paavo K J Kinnunen Joe Henry Steinbach

Neuroactive steroids can either potentiate or inhibit a variety of membrane channels. Most studies have suggested that the effects are mediated by specific association of the steroid with the affected channel. However, a recent study of the rho1 (GABA-C) receptor (Mol Pharmacol 66:56-69, 2004) concluded that the actions were consistent with an action of the steroid in the lipid bilayer to alter...

2014
Samira Afrazi Saeed Esmaeili-Mahani

OBJECTIVES Painful diabetic neuropathy is associated with hyperexcitability and hyperactivity of spinal cord neurons. However, its underlying pathophysiological mechanisms have not been fully clarified. Induction of excitatory/inhibitory neurotransmission imbalance at the spinal cord seems to account for the abnormal neuronal activity in diabetes. Protective properties of neurosteroids have bee...

Journal: :Journal of neurophysiology 2002
Qi-Ying Liu Yoong H Chang Anne E Schaffner Susan V Smith Jeffery L Barker

Although 3alpha-substituted metabolites of progesterone are well established to interact with GABA(A) receptor/Cl(-) channels, the nature of the interaction(s) remains uncertain. We used patch-clamp recording to study the interaction with GABA(A) receptor/Cl(-) channels expressed by embryonic hippocampal neurons differentiating in culture and nonneuronal cells transfected with GABA(A) receptor ...

2007
Jessica Strömberg Sven Geier

..................................................................................................... 6 ABBREVIATIONS....................................................................................... 7 LIST OF ORIGINAL PAPERS............................................................ 8 INTRODUCTION .......................................................................................... ...

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