نتایج جستجو برای: allopregnanolone

تعداد نتایج: 513  

2008
Maria Carolina Hardoy Claudia Sardu Liliana Dell'Osso Mauro Giovanni Carta

OBJECTIVES Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum concentrations of progesterone and allopregnanolone compared to healthy controls. Women with BD presented even higher levels than those affected b...

2016
Anette Lundqvist

III Sammanfattning på svenska VII Abbreviations IX Definitions used in the thesis XI Original papers XIII Preface 1 Introduction 2 Swedish antenatal care 3 Dietary recommendations 3 Dietary supplementation 5 Exposures to avoid or reduce 6 Weight gain and obesity 7 Behavioural changes; physical activity and diet 8 Vitamin D physiology and synthesis 9 Vitamin D in relation to pregnancy and after ...

2016
Victoria Schlegel Markus Thieme Carsten Holzmann Martin Witt Ulrike Grittner Arndt Rolfs Andreas Wree

Niemann-Pick Type C1 (NPC1) is an autosomal recessive inherited disorder characterized by accumulation of cholesterol and glycosphingolipids. Previously, we demonstrated that BALB/c-npc1nihNpc1-/- mice treated with miglustat, cyclodextrin and allopregnanolone generally performed better than untreated Npc1-/- animals. Unexpectedly, they also seemed to accomplish motor tests better than their sha...

Journal: :Neuron 1997
A. B Brussaard K. S Kits R. E Baker W.P.A Willems J. W Leyting-Vermeulen P Voorn A. B Smit R. J Bicknell A. E Herbison

We found that magnocellular oxytocin neurons in adult female rats exhibit an endogenous GABA(A) receptor subunit switch around parturition: a decrease in alpha1:alpha2 subunit mRNA ratio correlated with a decrease in allopregnanolone potentiation and increase in decay time constant of the GABA(A) receptor-mediated IPSCs in these cells. The causal relationship between changes in alpha1:alpha2 mR...

2011
Alessandro Faroni Valerio Magnaghi

Since the first observations on the existence of "neurosteroids" in the 1980s, our understanding of the importance of these endogenous steroids in the control of the central and peripheral nervous system (PNS) has increased progressively. Although most of the observations were made in neuronal cells, equally important are the effects that neurosteroids exert on glial cells. Among the different ...

2016
Kumar Shivam Amir Riyaz Khan Pankaj Taneja

-The decrease in hippocampal neurogenesis can lead to development of Alzheimer disease (AD), yet various hypothesis suggest that AD patient have increased neurogenesis in the region 1 of hippocampus proper (CA1 region). Ammon‟s horn (the principle region of Alzheimer‟s pathology) has been found to be involved in neuronal loss however the exact nature of neurogenesis is unknown. Insulin like gro...

Journal: :The international journal of neuropsychopharmacology 2014
Laura Modol Caty Casas Xavier Navarro Anna Llidó Monique Vallée Marc Pallarès Sònia Darbra

Allopregnanolone is a neurosteroid that has been reported to fluctuate during early developmental stages. Previous experiments reported the importance of neonatal endogenous allopregnanolone levels for the maturation of the central nervous system and particularly for the hippocampus. Changes in neonatal allopregnanolone levels have been related to altered adult behaviour and with psychopatholog...

2014
Neil J. Spratt Amelia J. Tomkins Debbie Pepperall Damian D. McLeod Mike B. Calford Shaida A. Andrabi

Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative neuroprotectants after ischemic stroke. We sought to confirm their effectiveness in a hypertensive rat stroke model, with intra- and post-operative temperature regulation. The primary study compare...

2017
Stephen J. Kanes Helen Colquhoun James Doherty Shane Raines Ethan Hoffmann David R. Rubinow Samantha Meltzer‐Brody

OBJECTIVE Preclinical evidence indicates that rapid changes in levels of allopregnanolone, the predominant metabolite of progesterone, confer dramatic behavioral changes and may trigger postpartum depression (PPD) in some women. Considering the pathophysiology of PPD (i.e., triggered by reproductive steroids), the need for fast-acting, efficacious treatments and the negative consequences of unt...

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