Background: Infertility, defined as the failure to conceive after one year of regular, unprotected intercourse, affects 50–80 million people worldwide. A male factor is involved in approximately 20–30% cases. In etiology infertility, association between poor semen quality and oxidative stress (OS) well known. High levels reactive oxygen species (ROS) allow oxidation DNA, proteins, lipids sperm ...

BACKGROUND Synthesis and apoenzyme attachment of lipoic acid have emerged as a new complex metabolic pathway. Mutations in several genes involved in the lipoic acid de novo pathway have recently been described (i.e., LIAS, NFU1, BOLA3, IBA57), but no mutation was found so far in genes involved in the specific process of attachment of lipoic acid to apoenzymes pyruvate dehydrogenase (PDHc), α-ke...

Alpha lipoic acid has both hydrophilic and hydrophobic properties is widely dispersed in cellular membranes the cytoplasm. It one of most powerful antioxidants for cells. The current research looked at possible therapeutic benefits alpha acid) a male rat model D-galactose-induced brain aging. G1 normal as control group, G2 animals were given 200 mg/kg bw.IP. daily D-gal group 30 days, G3 100 mg...

Spirulina and lipoic acid has been considered as one of the most effective in ant oxidative stress anti-inflammatory activity.Aspartame (ASP) is mostwidely used (artificial sweeteners)used a variety foods feeds.This study was conducted to evaluate possible protective effect alpha-lipoic against aspartame induced brain damage rabbits. Forty two white male New-Zealand Rabbits were classified into...

Background There are reports that indicate dietary alpha lipoic acid (ALA) supplementation enhances glucose uptake. The research was done with animal models and diabetic humans, but the effects of ALA supplementation on glucose uptake in healthy humans are unknown. The present study was designed to test the hypothesis that acute ingestion of ALA would enhance glucose uptake in healthy male subj...

The role of R-α-lipoic acid as a cofactor (lipoyllysine) in mitochondrial energy metabolism is well established. Lipoic acid non-covalently bound and exogenously administered to cells or supplemented in the diet is a potent modulator of the cell's redox status. The diversity of beneficial effects of lipoic acid in a variety of tissues can be mechanistically viewed in terms of thiol/disulfide ex...

The purpose of this study was to investigate the effects of α-lipoic acid on body weight and lipid profiles in Sprague-Dawley rats fed a high fat diet (HFD). After 4 weeks of feeding, rats on the HFD were divided into three groups by randomized block design; the first group received the high-fat-diet (n = 10), and the second group received the HFD administered with 0.25% α-lipoic acid (0.25LA),...

Alpha-lipoic acid, a potent antioxidant with multifarious pharmacological benefits has been reported to be neuroprotective in several neuronal models and used to treat neurological disorders such as Alzheimer's disease. Nonetheless, conclusive mechanisms of alpha-lipoic acid for its protective effects particularly in NG108-15 cells have never been investigated. In this study, the intricate neur...

Siliphos-selenium-methionine-alpha lipoic acid (SSMAL) has been used to treat chronic hepatic diseases, although formal evaluation of this mixture with clinical trials is lacking. We conduct this pilot study to investigate the safety and effectiveness of SSMAL in patients with non-alcoholic fatty liver disease (NAFLD). Forty NAFLD patients were randomized into two groups. All patients received ...