Tujuan utama terapi ansietas yakni mencapai remisi dan mencegah terjadinya kekambuhan. Dalam praktek klinik lebih sulit untuk dicapai, sehingga tujuan yang diharapkan ialah ketercapaian respon terapi. Berkaitan dengan hal tersebut, pilihan gangguan mempertimbangkan beberapa faktor. Salah satu umum digunakan menangani golongan benzodiazepin khususnya alprazolam. Penelitian ini bertujuan mengetah...

Melatonin a hormone is major product of the pineal gland. Alprazolam an anti-anxiety drug that belongs to benzodiazepines category. The quantity alprazolam and melatonin had been calculated by use regression equation responses were measured at 277 nanometers wavelength using above-mentioned conditions RP-HPLC simultaneous estimation has developed method determined for validation. was estimated ...

The presence of a degradation product of alprazolam tablets that emerged throughout a short-stability assay has been determined and properly characterized. For this purpose an efficient methodology has been successfully applied, including SPE and HPLC methods for isolation and purification, respectively. LC/MS, MS/MS, 1H NMR, 13C NMR, UV and IR have been employed for structural elucidation conf...

We report a comparative study on the photodegradation of the widely used benzodiazepine psychoactive drug alprazolam (8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, ALP) using direct photolysis, and titanium dioxide photocatalyzed reaction. Titanium dioxide photocatalysts were prepared as nanoparticles by acidic sol-gel methods, calcined at two different temperatures, ...

Low rates of benzodiazepine discontinuation have been seen in longterm outcome studies of alprazolam-treated panic disorder. Discontinuation studies reveal high rates of relapse when alprazolam is stopped. Available data may lack relevance to clinical practice, however, because drug taper rates are often more rapid than those used in many clinical settings. In order to obtain naturalistic data ...

CONTEXT St John's wort is a popular herbal product used to treat depression but it has been implicated in drug interactions. OBJECTIVE To assess the potential of St John's wort administration to alter the activity of the cytochrome P450 (CYP) enzymes extensively involved in drug metabolism. DESIGN, SETTING, AND PARTICIPANTS Open-label crossover study with fixed treatment order conducted Mar...

A woman in her sixties with a normal medical history was admitted to general floor Neuropathic pain symptoms such as burning sensation throughout body (head, back, spine, throat, and tongue dry mouth, chest, abdomen, kidneys, thighs, toes), inability eat, urinary incontinence, difficulty wearing clothing, leaning on the back. There delay diagnosing patient's condition, which confirmed have seve...

Objective: Stress and cortisol increase blood glucose. Considering the role of central catecholaminergic pathways on hypothalamic-pituitary adrenocortical axis, and results of some studies that alprazolam (a benzodiazepine) has inhibitory effect on catecholamines, it seems that alprazolam may reduce blood glucose. The aim of this study was to evaluate the effect of alprazolam on serum insulin l...

INTRODUCTION Stress can cause harmful effects in the body that induce a wide range of biochemical and behavioural changes. As anti-stress drugs are routinely used to combat stress hence study is needed to assess the contraindication of these drugs in the physiological systems. AIM To investigate the effect of alprazolam on restrained stress induced alteration of serum cortisol, and antioxidan...

Alprazolam belongs in the group of anxiolytics, medicaments used for reducing anxiety. As most other drugs, it can cause various adverse events, including hormonal disturbances and imbalance. Prolactin elevation is one such hormonal adverse event that can lead to galactorrhoea, or abnormal milk discharge from the breast and amenorrhoea. In this case report we will present the case of a female p...