Objective Sleep deprivation is known to affect driving behavior and may lead serious car accidents similar the effects from e.g., alcohol. In a previous study, we have demonstrated that use of machine learning techniques allows adequate characterization abnormal after alprazolam and/or alcohol intake. present extend this approach sleep test model for new interventions. We aimed classify depriva...

Dissolution study was carried for alprazolam solubility study, conditions selected for paddle was 100 rpm, using 500 ml potassium dihydrogen phosphate of pH 6.8 at temperature as 37°C. These conditions are useful for % release of alprazolam was achieved on symmetyshield RP8 (150 x 3.9 mm i.d, 5 μ.) column was most suitable for dissolution study with mixture of (60:40 % v/v) of buffer and aceton...

Interactions of mu-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects of the opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose...

BACKGROUND Adjustment disorder with anxiety (ADWA) is a highly prevalent condition, particularly in primary care practice. There are relatively few systematic treatment trials in the area of ADWA, and there are few data on predictors of treatment response. Etifoxine is a promising agent insofar as it is not associated with dependence, but in primary care settings benzodiazepines continue to be ...

OBJECTIVE To evaluate use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. DESIGN Prospective open clinical trial. ANIMALS 40 dogs with storm phobia. PROCEDURE Dogs received clomipramine at a dosage of 2 mg/kg (0.9 mg/lb), PO, every 12 hours for 3 months; then 1 mg/kg (0.45 mg/lb), PO, every 12 hours for 2 weeks; then 0.5 mg/kg (0.23 mg/lb), PO...

OBJECTIVE To review the efficacy of anxiolytics (alprazolam and azapirones) in major depressive disorder (MDD) and that of antidepressants in generalized anxiety disorder (GAD), thereby exploring the possible theoretical and clinical implications of this efficacy. METHOD A Medline literature search was performed for the period January 1980 to September 1997 of randomized, double-blind compari...

Siberian ginseng ([SG]; Eleutherococcus senticosus) is a commonly used herbal preparation. The objective of this study was to assess in normal volunteers (n = 12) the influence of a standardized SG extract on the activity of cytochrome P450 CYP2D6 and 3A4. Probe substrates dextromethorphan (CYP2D6 activity) and alprazolam (CYP3A4 activity) were administered orally at baseline and again followin...

Corticotropin-releasing factor (CRF) is the major physiologic regulator of the hypothalamic-pituitary-adrenal (HPA) axis and plays a key role in coordinating the mammalian stress response. Substantial data implicates hyperactivity of CRF neuronal systems in the pathophysiology of depression and anxiety disorders. Enhanced CRF expression, release, and function have also been demonstrated during ...