Accelerated life test (ALT) is currently the main method of assessing product reliability rapidly, and the design of effi‐ cient test plans is a critical step to ensure that ALTs can assess the product reliability accurately, quickly, and economi‐ cally. With the promotion of the national strategy of civil‐military integration, ALT will be widely used in the research and development (R&D) of va...

BACKGROUND Serum alanine aminotransferase (ALT) is a marker of liver injury. The 2005 American Gastroenterology Association Future Trends Committee report states that serum ALT levels remain constant with age. This study examines the association between serum ALT and age in a community-dwelling cohort in the United States. METHODS A cross-sectional study of 2,364 (54% female) participants age...

Lamivudine belongs to the set of antiviral agents effective against hepatitis B virus infection. Given case reports on liver injuries after certain antiviral agent treatments, this study examined the effects of lamivudine on alanine aminotransferase (ALT) and total bilirubin (TB) using a medical system database. A total of 1,321 patients taking lamivudine alone or with others were evaluated usi...

To understand the mechanisms underlying the discordance between normal serum alanine aminotransferase (ALT) levels and significant alterations in liver histology of chronic hepatitis B virus (HBV) infection with persistent normal ALT (PNALT) or minimally elevated ALT. A total of 300 treatment-naive chronic HBV-infected patients with PNALT (ALT ≤ upper limit of normal [ULN, 40 U/ml]) or minimall...

BACKGROUND The upper normal limit (ULN) of serum alanine-aminotrasferase (ALT) normal range was recently challenged, because patients diagnosed with liver diseases may have 'normal' or near-'normal' ALT levels, and because possible modulators are often ignored in determining normal range. AIM To estimate the ULN for serum ALT and to identify factors modulating it. SUBJECTS AND METHODS We re...

BACKGROUND A certain proportion of hepatitis B virus (HBV)-infected patients with persistently normal alanine transaminase (ALT) levels have significant fibrosis. Using liver stiffness measurements (Fibroscan®) and laboratory data, including serum ALT, quantitative HBsAg (qHBsAg), and HBV DNA, we attempted to predict the natural histories of these patients. METHODS Non-cirrhotic HBeAg-negativ...

Results We studied 143 children (92 M/51 F) aged 2.4 15.6 years. Negative results were found in 20 (14%) with Alternaria, 24 (16.8%) with Alt 1, and 19 with both (13.3%). There was a good correlation between the two determinations (r = 0.935, p <0.001). Overall the levels were higher for Alt a 1 (18.9 ± 24.4) than for Alternaria (15.4 ± 20.1). There were 97 cases (68%) with levels of Alt a 1 > ...

An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties. We hypothesized that alt-PSMA would have activity against human immunodeficiency virus type 1 (HIV-1) comparable to other polyanions, such as the related compound, ...

Several studies suggest that a substantial number of patients with normal serum alanine aminotransferase (ALT) levels, defined by current thresholds, have ongoing hepatic necro-inflammation and fibrosis, and are at risk of liver disease progression. A major problem lies in the definition of normality. The current upper limit of normal (ULN) for ALT was established in the 1980s when reference po...