El cerebro humano ha sido descrito como un sistema complejo. Su estudio por medio de señales neurofisiológicas desvelado la presencia interacciones lineales y no lineales. En este contexto, se han utilizado métricas entropía para descubrir el comportamiento cerebral en ausencia alteraciones neurológicas. mapeo es gran interés enfermedades neurodegenerativas progresivas enfermedad Alzheimer. obj...

As neurons age, their survival depends on eliminating a growing burden of damaged, potentially toxic proteins and organelles-a capability that declines owing to aging and disease factors. Here, we review the two proteolytic systems principally responsible for protein quality control in neurons and their important contributions to Alzheimer disease pathogenesis. In the first section, the discove...

Este trabalho tem como tema central a vulnerabilidade do idoso com Doença de Alzheimer (DA), abordado por meio revisões integrativas da literatura. Objetivo: analisar quais as principais ações referentes à assistência e cuidados enfermagem ao doença Alzheimer, bem condutas adotadas pelos familiares relatadas na Método: Trata-se uma pesquisa desenvolvida pela revisão integrativa, resultados anál...

Neuropathologic changes in the temporal lobe, including focal atrophy of the subiculum and entorhinal cortex, have been described in association with Alzheimer disease. We studied the usefulness of detecting temporal-lobe structural changes on CT in making the diagnosis of Alzheimer disease. The dementia imaging protocol we use includes thin-section (5 mm) cuts of the temporal lobe oriented 20 ...

PURPOSE To examine the value of measurement of the interuncal distance in the diagnosis of mild to moderate Alzheimer disease. METHODS We measured interuncal distance from coronal MR scans acquired on a 1.5-T imager. We estimated interuncal distance from a total of 141 subjects: 54 patients diagnosed according to the National Institute of Neurological and Communicative Disorders and the Alzhe...

SEVERAL FINDINGS SUGGEST THAT oxidative stress may play an important role in the pathogenesis of Alzheimer disease. First, the brains of patients with Alzheimer disease contain lesions that are typically associated with exposure to free radicals. In addition, oxidative stress in brains of Alzheimer patients is indicated by elevated cerebral levels of endogenous antioxidants that scavenge free r...

Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer disease, no mechanistic explanation exists so far. We developed a model of hypertension, obtained by transverse aortic constriction, leading to alterations typical of Alzheimer disease, such as amyloid plaques, neuroinflammation, blood-brain barrier dysfunction, and cognitive impairment, shown...

Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer disease, no mechanistic explanation exists so far. We developed a model of hypertension, obtained by transverse aortic constriction, leading to alterations typical of Alzheimer disease, such as amyloid plaques, neuroinflammation, blood-brain barrier dysfunction, and cognitive impairment, shown...

Risk factors for developing Alzheimer disease include hypercholesterolemia, hypertension, obesity, and diabetes. Due to lack of effective treatments for Alzheimer disease, nutrition and primary prevention becomes important.

objectives: the purpose of this study was to explore the general health status in women as care givers of the elderly people with alzheimer who attending to the iranian association of alzheimer’s disease. methods & materials: in this descriptive –cross sectional study as a introductory stage of a randomized controlled field trial, 150 women were recruited with a consecutive sampling method. the...