Alzheimer disease is characterized by cerebral Abeta deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Abeta-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These da...

Cuidar de pessoas com doenças neurodegenerativas representa um desafio na sociedade atual. Objetivo: Analisar os conteúdos relacionados ao cuidado da pessoa Doença Alzheimer disponíveis em aplicativos móveis. Método: Revisão sistematizada do termo “Alzheimer” lojas virtuais para sistemas operacionais Android® e iOS® abril 2019. Resultados: identificaram-se 47 língua portuguesa foco principal at...

OBJECTIVE To examine change in cognitive function in older persons sampled from a community population, and its relation to age and Alzheimer disease. DESIGN Prospective cohort study with an average of 3.5 years of follow-up. SETTING East Boston, Mass--a geographically defined, urban, working-class community. PARTICIPANTS A stratified, random sample of persons 65 years and older underwent...

BACKGROUND Alzheimer disease is characterized by cognitive decline, senile plaques of β-amyloid (Aβ) peptides, neurofibrillary tangles composed of hyperphosphorylated τ proteins and neuronal loss. Aβ and τ are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are serine-threonine protein kinases activated by phosphorylation and involved in neuronal death. METHOD...

BACKGROUND Alzheimer disease is an increasingly common condition in older people. Knowledge of life expectancy after the diagnosis of Alzheimer disease and of associations of patient characteristics with survival may help planning for future care. OBJECTIVE To investigate the course of Alzheimer disease after initial diagnosis and examine associations hypothesized to correlate with survival a...

BACKGROUND There has been no analysis of brain tissue from longitudinally observed, cognitively tested patients to validate whether anti-inflammatory medications protect against the pathological changes of Alzheimer disease. OBJECTIVE To investigate the role of anti-inflammatory medications in alleviating the pathological features of Alzheimer disease. DESIGN AND MAIN OUTCOME MEASURES A 5-y...

BACKGROUND AND PURPOSE Elevated blood pressure has been found to increase the risk of dementia, including Alzheimer disease. We sought to investigate whether pulse pressure was predictive of Alzheimer disease and dementia. METHODS A community-based, dementia-free cohort (n=1270) aged > or =75 years was clinically examined twice over 6 years to detect incident dementia with the use of the crit...

OBJECTIVE The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer disease and dementia. However, it remains unclear whether plasma levels of apoE confer additional risk. We tested this hypothesis. METHODS Using 75,708 participants from the general population, we tested whether low plasma levels of apoE at study enrollment were associated with increased risk of futur...

Alzheimer disease is a neurodegenerative disorder that is the most commoncause of dementia amongthe elderly. The neurophathological evidences have demonstrated that cholinergic functions declined in the basal forebrain and cortex in senile dementia of the Alzheimer type1>2). Accordingly, enhancement of cholinergic neurotransmission have been considered as one potential therapeutic approach agai...