There is mounting evidence showing that mitochondrial damage plays an important role in Alzheimer disease. Increased oxygen species generation and deficient mitochondrial dynamic balance have been suggested to be the reason as well as the consequence of Alzheimer-related pathology. Mitochondrial damage has been related to amyloid-beta or tau pathology or to the presence of specific presenilin-1...

BACKGROUND AND PURPOSE Because the diagnostic significance of cortical superficial siderosis for Alzheimer disease and the association between cortical superficial siderosis and the topographic distribution of cerebral microbleeds have been unclear, we investigated the association between cortical superficial siderosis and clinicoradiologic characteristics of patients with cognitive impairment....

BACKGROUND/AIM Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish ...

Introdução: A Doença de Alzheimer (DA) é uma doença neurodegenerativa que se classifica como a forma mais comum demência em idosos. Frente isso e falta um tratamento medicamentoso efetivo, investiga-se diferentes dietas grupos alimentares são capazes modular frear patologia desenvolvimento da doença. Objetivo: analisar influência específicas seus componentes na prevenção ou proteção contra o ag...

El presente estudio pretende visibilizar los efectos de la práctica musicoterapia en personas con Alzheimer. Para ello se ha hecho un seguimiento prolongado periodo tiempo dos meses grupo entre ocho y diez dicha enfermedad. En inicio marcaron una serie objetivos a conseguir pacientes. Estos están centrados sobre todo mejora estimulación memoria. La evaluación progreso llevó cabo partir tabla qu...

Dementia is one of the facts than most contributes to the disability and dependence in elderly people. Alzheimer´s disease is the cause more common of dementia in the world. In Mexico, the prevalence of Alzheimer´s disease is 7.3% and incidence of 27.3 per 1,000 people/year. Mexican population studies have determined that Alzheimer´s disease is highly associated to women and their risk to devel...

Interleukin 1, an immune response-generated cytokine that stimulates astrocyte proliferation and reactivity (astrogliosis), was present in up to 30 times as many glial cells in tissue sections of brain from patients with Down syndrome and Alzheimer disease compared with age-matched control subjects. Most interleukin 1-immunoreactive glia in Down syndrome and Alzheimer disease were classified as...

BACKGROUND Zinc is one of the most important elements for human body. Zinc deficiency can occur in any age, if it is seen in elderly its clinical results can be more harmful due to already diminished functions. Some studies showed zinc deficiency has an important role in the pathogenesis of Alzheimer disease. In this study we measured the nail zinc levels and aimed to show its clinical implicat...

PURPOSE OF REVIEW This review outlines a practical approach to the history, mental state, neurologic examination, and laboratory tests in the diagnosis of dementia. RECENT FINDINGS Proposed new diagnostic criteria for Alzheimer disease recognize that nonamnestic presentations with symptoms that predominantly affect language, visuospatial abilities, or executive function may occur, particularl...

OBJECTIVE To disclose a novel mutation of the presenilin 1 (PS1) gene responsible for early-onset Alzheimer disease and to clarify genotype-phenotype correlation that should help to establish the function of this protein. BACKGROUND The PS1 and presenilin 2 (PS2) genes carry missense mutations in families with Alzheimer disease. The PS1 and PS2 proteins have similar structures, and all presen...