Dynamics of transforming potential underlie the systems of heterogeneous progression to a final demented state in Alzheimer patients. Such dynamics reflect many of the attributes of an essentially variable vascular series of substrates that implicate various component systems of the blood brain barrier as endothelium and also of the subcortical structures and cortex as further delineated by sys...

Alzheimer’s disease is the most common form of age-related dementia. Early-stage diagnosis of Alzheimer is of major importance for the following reasons: Also easily curable conditions like depression, poor nutrition and drug side effects may cause symptoms like early-stage Alzheimer. Moreover, recently some medications have been developed which successfully attenuate the symptoms and delay the...

---------------------------------------------------------------------***--------------------------------------------------------------------Abstract Alzheimer’s disease is most common cause of dementia and involves a progressive degeneration of the cerebral cortex. It is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. In Alzheimer disease death of the br...

Introduction: Iron oxide nanoparticles (Fe2O3-NPs) are small magnetic particles that widely used in different aspects of biology and medicine in modern life. Fe2O3-NP accumulated in the living cells due to absence of active system to excrete the iron ions so damages cellular organelles by highly reactivity. Method: Herein cytotoxic effects of Fe2O3-NP with 50 nm size were investigated on prima...

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donepezil, a member of the acetylcholinesterase inhibitor family, is approved for management of cognitive impairments as well as behavioral complications in patients with neurodegenerative alzheimer's disease. generally, donepezil is regarded as a safe medication in patients with alzheimer's disease although there have been reports of several minor adverse events including gastrointestinal dist...

background: alzheimer’s disease (ad) is a progressive neurodegenerative disease and nowadays the role of endothelial cell (ec) injury has been proposed in pathological process in ad. peroxisome proliferator‑activated receptor‑γ (ppar‑γ) agonist has anti‑inflammatory properties through activation in glial cells and improves vascular function and prevent atherosclerotic disease progression. the a...

objectives: since support for family caregivers is crucial in providing care for elderly, this study was conducted to examine the effects of participation in support groups on alzheimer’s family caregivers’ strain and spiritual wellbeing. materials and methods & materials: in this semi-experimental study, 32 accessible family caregivers of elderly patients with alzheimer who had at least one ye...

the crude methanolic extract of the seeds of celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (ad) activity. the extracts showed prominent dpph free radical scavenging activity, inhibiting activity of authentic peroxynitrite (onoo-) and inhibition of total reactive oxygen species (ros) generation. in dpph radical scave...