Objetivo: Analisar se há correlação entre exercício físico, com o declínio ou manutenção da função cognitiva em idosos doença de Alzheimer. Métodos: revisão sistemática metanálise ensaios clínicos randomizados, que investigaram a relação do físico na Alzheimer, publicados nas bases: Pubmed, Pedro, Lilacs e Ebsco, sem período publicação delimitado. Resultados: Foram encontrados 220 artigos. Dest...

Este artigo tem por objetivo realizar uma varredura da literatura médica vigente sobre as novas perspectivas de tratamento para os pacientes com Doença Alzheimer. Foram utilizados como motores busca indexadores Google Scholar, Scielo, Pubmed e Web of Science seleção dos artigos, através unitermos “doença Alzheimer; demência; proteína β amilóide; tau fosforilada; neurodegeneração; tratamento; te...

neurodegenerative disease are characterized by the progressive loss of neurons from specific origins of the cns .alzheimer disease (ad) is a neurodegenerative disorder which affect brain regains that control memory and ability to learn. it is estimated that 27 million people are affected word wide and this number is expected to triple by 2050 due to increase of the population life expectancy. a...

objective(s): neuroprotective effect of creatine (cr) against β-amyloid (aβ) is reported in an in vitro study. this study investigated the effect of cr supplementation on β-amyloid toxicity in vivo. materials and methods: thirty two, male wistar rats were divided into 4 groups. during ten weeks of study, control group went through no surgical or dietary intervention. at the 4th week of study sh...

See related article, pages 345–350. Stroke and Alzheimer disease are major public health burdens that account for substantial disability and extensive cost.1,2 In addition, these diseases currently tie as the third most common cause of death in the United States,3 and both will become more important as life expectancy increases. Annually, 15 million people worldwide experience a stroke, of whic...

BACKGROUND AND PURPOSE Dilated perivascular spaces have been shown to be a specific biomarker of cerebral small-vessel disease in young patients with dementia. Our aim was to examine the discriminative power of dilated cerebral perivascular spaces as biomarkers of small-vessel disease in a very elderly population of patients with dementia. MATERIALS AND METHODS We studied healthy volunteers (...

Alzheimer disease is the most common form of dementia, affecting nearly one-half [corrected] of Americans older than 85 years. It is characterized by progressive memory loss and cognitive decline. Amyloid plaque accumulation, neurofibrillary tau tangles, and depletion of acetylcholine are among the pathologic manifestations of Alzheimer disease. Although there are no proven modalities for preve...

Background: Thymus persicus is one of the Iranian endemic medicinal plants, that its decoction and various products have plenty of food and pharmaceutical uses. Objective: Evaluation of T. persicus products metabolite contains and determination of the best antioxidant, anti-diabetic and anti-Alzheimer extract. Methods: Samples total phenolic, flavonoid and tannin contents were determined by F...

BACKGROUND Psychosis is common in patients with Alzheimer disease. While the relationship between psychosis and clinical variables has been examined frequently, few studies have examined the relationship between psychosis and the 2 major neuropathological hallmarks of Alzheimer disease: neurofibrillary tangles and senile plaques. We characterized the occurrence of psychosis in relation to demen...