BACKGROUND AND PURPOSE CSF volumes in the basal cistern and Sylvian fissure are increased in both idiopathic normal pressure hydrocephalus and Alzheimer disease, though the differences in these volumes in idiopathic normal pressure hydrocephalus and Alzheimer disease have not been well-described. Using CSF segmentation and volume quantification, we compared the distribution of CSF in idiopathic...

Recombinant adenovirus serotype 3 (rAd3), which infects cells through the receptor desmoglein 2 (DSG2), has been investigated as a vector for gene therapy or vaccination. However, pre-existing anti-vector immunity may limit the practical application of rAd3. In this study, we investigated the seroprevalence and neutralizing antibody (NAb) titers to Ad3 and alternate serotypes in normal healthy ...

The majority of adenovirus serotypes can bind to the coxsackievirus and adenovirus receptor (CAR) on human cells despite only limited conservation of the amino acid residues that comprise the receptor-binding sites of these viruses. Using a fluorescence anisotropy-based assay, we determined that the recombinant knob domain of the fiber protein from adenovirus serotype (Ad) 2 binds the soluble, ...

abstract alzheimer’s disease (ad) is the most common cause of dementia in elderly people. the prevalence of alzheimer diseases is increasing in the world due to population aging. metabolic disease such as diabetes and obesity play important role in alzheimer disease. hyperglycemia can play important role in brain damage. it causes cognitive impairments, functional and structural alterations in ...

Objectives: This study evaluates the effects of 8 weeks of resistance exercises on the expression of neurotrophins and Trk receptors in Alzheimer model male Wistar rats. Methods: For this purpose, 32 mature male Wistar rats with a mean weight of 230-280 g were chosen and divided into Alzheimer and Sham groups. The rats in the sham group received normal saline, while the ones in the Alzheimer g...

background: the seladin-1 (selective alzheimer disease indicator-1), also known as dhcr24, is a gene found to be down-regulated in brain region affected by alzheimer disease (ad). whereas, hair follicle stem cells (hfsc), which are affected in with neurogenic potential, it might to hypothesize that this multipotent cell compartment is the predominant source of seladin-1. our aim was to evaluate...

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...

patients with alzheimer's disease have cognitive deficits, impaired long-term potentiation and learning and memory. a progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in alzheimer’s disease (ad). in the current project a new series of phthalimide derivatives were synthesized. p...

Introducción: el Alzheimer es la forma más común de demencia y una las primeras causas discapacidad. Objetivo: describir si en pacientes con acompañamiento familiar, comparación abandono, ralentiza evolución esta enfermedad. Metodología: revisión integrativa. Se seleccionaron artículos los últimos cinco años, idioma inglés, español portugués, disponibles bases datos PubMed, EBSCO HOST, Scielo, ...