BACKGROUND In the last decade, many studies have reported abnormal connectivity within the default mode network (DMN) in patients with Alzheimer disease. Few studies, however, have investigated other networks and their association with pathophysiological proteins obtained from cerebrospinal fluid (CSF). METHODS We performed 3 T imaging in patients with mild Alzheimer disease, patients with am...

BACKGROUND Few studies have investigated the effects of dietary fats on the development of Alzheimer disease. We examined the associations between intake of specific types of fat and incident Alzheimer disease in a biracial community study. METHODS We performed clinical evaluations on a stratified random sample of 815 community residents aged 65 years and older who were unaffected by Alzheime...

Alzheimer's disease (AD) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. The exact cause of Alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. This brings in mind using non-steroidal anti-inflammatory drugs (NSAID) as treatment or prevention of the disease. ...

Doença de Alzheimer é uma enfermidade neurodegenerativa gradativa, a qual tem relação com idade, expressa através do dano cognitivo e da memória, implicação das tarefas diárias diversidade sintomas neuropsiquiátricos, além mudanças comportamentais. Este estudo teve por objetivo compreender influência nutrição no desenvolvimento progressão Alzheimer. Trata-se revisão literatura artigos científic...

La enfermedad de Alzheimer es un trastorno neurológico inevitable en el que la muerte las células cerebrales provocan pérdida memoria y deterioro cognitivo desencadena demencia, siendo causa más común demencia ancianos. Generalmente, se desarrolla personas mayores 65 años incrementando su incidencia aquellos pacientes edad aún avanzada. Se considera una principales causas a nivel mundial. El al...

In Alzheimer disease, increased b-secretase (BACE1) activity has been associated with neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus, inactivation of BACE1 could be important in the treatment of Alzheimer disease. In this study, we found that lowering BACE1 levels using lentiviral vectors expressing siRNAs targeting BACE1 reduced amyloid production and the ...

Este estudo objetiva apresentar tipos de nutrição clínica relacionados à doença Alzheimer. A proposta é explicar a doença, abordar prevenções e o processo nutricional para que Alzheimer possa ser evitada, assim como destacar importância do acompanhamento indivíduos sofrem dessa desde seu estágio inicial. escolha deste tema no desenvolvimento trabalho académico ocorreu em virtude da necessidade ...

BACKGROUND/AIM Pathophysiological changes due to Alzheimer disease and increasing age might result in situations requiring forensic evaluation in the elderly. Judicial bodies might need forensic evaluation of trauma and the decision-making capacity of Alzheimer patients. This study aimed to determine the demographic and clinical characteristics of Alzheimer patients seen for forensic evaluation...

Alzheimer disease is a devastating neurodegenerative disorder affecting millions of Americans. It reduces the ability of the individual to remain independent, places a burden on caregivers, and substantially increases healthcare costs. New treatments are being tested in numerous clinical trials with the goal of preventing or delaying the onset of Alzheimer disease, slowing or modifying the dise...

Este trabalho teve como objetivo investigar por meio de uma revisão integrativa da literatura, a possível correlação entre doença periodontal e Alzheimer. Realizou-se um levantamento bibliográfico integrativo, fim trabalhos que versem sobre Doença Periodontal Alzheimer, buscou-se com textos completos originais publicados 2017 2022, nas bases Medline LILACS. A pergunta norteadora do estudo formu...