Prediction of Alzheimers disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end we combine a predictive multi-task machine learning method1 with novel MR-based multivariate morphometric surface map of the hippocampus2 to predict future cognitive scores of patients. Previous work...

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Magnetic resonance imaging (MRI) allows to display brain structures with highest resolution. To fully exploit the potential of this imagining modality, data mining methods are required to reveal subtle differences in brain structure caused by disorders such as Mild Cognitive Impairment (MCI) and early stage Alzheimers disease (AD). In this paper, we propose a data mining framework which combine...

cognize this dilemma might encourage them to develop functional teams. Individual neurologists and geriatricians could continue to diagnose routine neurological problems referred to them. In addition, they could subspecialize so that each might have a specific input in a multidisciplinary team which focused, for example, on the diagnosis and continuing care of the big three: stroke, the epileps...

Alzheimer's disease (AD) is the most common neurodegenerative disorder. Currently available therapies are symptomatic but do not alter underlying disease progression. Immunotherapeutic approaches such as anti Aβ peptide active vaccination trials have had limited success to date. Intravenous immunoblobulin (IVIg) is widely used in immune-mediated neurological disorders such myasthenia gravis and...

We previously have found biofilms in the hippocampi of Alzheimer’s disease (AD) post mortem brain specimens. We had seen them in an extracellular location and noted them to be present in the areas of pathological plaque formation. Other investigators have found the presence of spirochetes (Lyme and dental) in affected (AD) brains, and these have been correlated with Treponema pallidum. In a rec...

Much experimental evidence suggests that age-related brain pathologies are most often mediated by reactive oxygen species primarily originating from mitochondria (mROS). Two papers with such evidence have been recently published in the Journal of Alzheimer's Disease (Stefanova et al., J Alzheimers Dis 21, 476-491, 2010; Lloret et al., J Alzheimers Dis, doi: 10.3233/JAD-2011-110890). In the firs...