objective: withdrawal symptoms are a main reason of continuous use of opioid. this study compares the efficacy of augmentation of amantadine with clonidine in decreasing opioid withdrawal symptoms. methods: this double-blind randomized clinical trial was carried out in the detoxification and rehabilitation inpatient ward at razi hospital, tabriz, iran during 2012. the patients were randomly ass...

We carried out a double blind control study of fatigue in 32 patients with multiple sclerosis, comparing amantadine hydrochloride 100 mg twice a day and placebo. On amantadine 31% had marked improvement; 15.6% moderate improvement; 15.6% mild improvement; and 36.5% unchanged. On placebo, none noted marked improvement; one claimed moderate improvement on either amantadine or placebo. 18.7% repor...

Amantadine is frequently used in addition to dopaminergic substances like dopamine agonists or L-Dopa in advanced Parkinson disease (PD). However, adverse effects like hallucinations limit its use. PD patients developing severe psychotic symptoms upon treatment with either dopaminergic substances and/or amantadine need to stop intake of any psychotropic substance. Here, we report the case of a ...

We performed a double-blind cross-over study with amantadine hydrochloride in 12 patients with Friedreich's disease and 2 with autosomal dominant cerebellar ataxia. Patients were randomly assigned to a placebo-amantadine or amantadine-placebo sequence. The interval between the treatments was two weeks. Patients were graded according to a functional ataxia scoring scale and videotaped in basal c...

BACKGROUND Amantadine is known to be a noncompetitive N-methyl-D-aspartate receptor antagonist and may be useful in preventing postoperative central sensitization, acute opioid tolerance, and opioid-induced hyperalgesia, thereby decreasing pain and analgesic requirements. The aim of this pilot study was to evaluate the effects of perioperative oral amantadine on postoperative pain and analgesic...

BACKGROUND Amantadine hydrochloride and rimantadine hydrochloride are recommended by the Centers for Disease Control and Prevention for prophylaxis of influenza A. While data suggest that rimantadine is better tolerated, there are no data examining the rate of adverse reactions in elderly patients who receive amantadine vs rimantadine. Our objective was to assess the adverse reaction rate in el...

conclusions these results provide empirical support for conducting a further study on comparing different add-on strategies for treating drug-induced sd. background antidepressant-induced sexual dysfunction (sd) is a common problem, associated with a significant risk of non-adherence. selective serotonin reuptake inhibitors (ssris) are associated with a substantial risk of sd. only 10 % of pati...

Background & Aims: Various antiviral drugs such as amantadine are used to treat influenza. This drug is categorized in group C and few researches have been conducted about its toxic effects on human fetus. In the current study, the pathologic effects of the drug as well as drug efficacy in reducing influenza virus titer in the developing chicken embryo were assessed. <br ...

Amantadine is known to block the M2 proton channel of the Influenza A virus. Here, we present a structure of the M2 trans-membrane domain blocked with amantadine, built using orientational constraints obtained from solid-state NMR polarization-inversion-spin-exchange-at-the-magic-angle experiments. The data indicates a kink in the monomer between two helical fragments having 20 degrees and 31 d...

Amantadine transport into renal proximal and distal tubules is bicarbonate dependent. In the present study, we addressed the effects of bicarbonate on renal clearance and urinary excretion of amantadine. Renal clearance of kynurenic acid was also studied to determine whether bicarbonate effects are specific for organic base transport by the kidney. After a moderate diuresis was established, ani...