Positive results in the Ames test correlate well with carcinogenic potential in rodents. This correlation is not perfect because mutations are only one of many stages in tumour development. Also, situations can be envisaged where the mutagenic response may be specific to the bacteria or the test protocol, e.g., bacterial-specific metabolism, exceeding a detoxification threshold, or the inductio...

Lafoensia pacari (Lythraceae), popularly known in Brazil as "pacari", is a small tree native to the Cerrado that is used in folk medicine to treat cancer and as an anti-inflammatory and cicatrizing agent. We evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic activities of an ethanol extract of L. pacari stem bark (EESB) using the Ames test and the mouse bone marrow micronucleu...

Sister-chromatid exchange (SCE) and chromosome aberrations (CA) in bone marrow cells were analyzed after in vivo exposure in mice to 4 aliphatic epoxides, namely 1-naphthyl glycidyl ether (NGE), 1-naphthyl propylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE) and trichloropropylene oxide (TCPO). These compounds were selected as being among the most mutagenic aliphatic epoxides in our previ...

The Ames Salmonella/microsome mutagenicity assay (Salmonella test; Ames test) is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances that can produce genetic damage that leads to gene mutations. The test employs several histidine dependent Salmonella strains each carrying different mutations in various genes in the histidine operon. ...

The AMES Wholesale Power Market Test Bed is an agent-based computational laboratory designed for the systematic experimental study of restructured wholesale power markets. These notes show how AMES can be recast in more standard state-space equation form. The result is a highly nonlinear and highly coupled system of first-order stochastic difference equations. The AMES state-space equation repr...

Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory and antioxidant effects. The leaves of the olive tree (Oleaeur opaea) have been used for medicinal purposes since ancient times and research has suggested that olive leaf extracts have antimicrobial and antimutagenic properties. In this study, Olive leaf aqueous extracts were screened for their ...