Sulfur mustard is well known as toxic Chemical warfare agent and on contact with skin it produces blisters as well as systemic toxicity. In this study we have evaluated the efficacy of few analogues of S-2(2-amino-ethylamino) ethyl phenyls sulphide (DRDE-07) and a known radioprotector amifostine against SM induced toxicity in mouse. We have selected seven newly synthesized analogues of DRDE-07 ...

Subcutaneous administration of amifostine: A promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy. Oxaliplatin, a third-generation platinum compound with a 1,2-diaminocyclohexane (DACH) carrier ligand, is a recently developed agent with a broad spectrum of antineoplastic activities [1]. Hallmarks of this novel agent include its lack of cross-resistan...

The title compound, (C(4)H(8)N(3)O)(H(3)O)[Ni(C(7)H(3)NO(4))(2)]·3H(2)O, exhibits isotypism with its Co(II) analogue. All intramolecular distances and angles are similar for the two structures. This applies also for the intermolecular forces, consisting of O-H⋯O and N-H⋯O hydrogen bonds and π-π interactions [with centroid-centroid distances of 3.428 (2) and 3.579 (2) Å], that lead to a cohesion...

The absolute configuration of the octa-hedral fac-CoN(3)O(3) title complex, [Co(C(5)H(8)NO(2))(3)]·3H(2)O, has been determined by single-crystal X-ray analysis. A three-dimensional network of hydrogen bonds is observed between the proline carboxyl-ate groups and the three uncoordinated water mol-ecules.

Radiation treatment is an important therapeutic option for a number of malignancies (American Cancer Society), but its use is frequently limited by adverse effects on normal tissues (Stone et al., 2003). Thus, the goal of most oncology treatments is to maximize the antineoplastic effect while minimizing deleterious outcomes for the patient. WR-2721 was developed by the U.S. Army Anti-Radiation ...

PURPOSE The aim of this study was to determine if fractionation and individual or combinations of radioprotectants could minimize damage to physeal longitudinal growth in an animal model to any greater extent than fractionation alone. MATERIALS AND METHODS Sixty-three weanling male Sprague-Dawley rats were randomized into seven equal groups. Five groups received a total 25 Gy radiation exposu...

The acceptable treatment strategy currently in the of locally advanced non-small cell lung cancer (LA-NSCLC) patients is combination treatment, but concurrent chemoradiotherapy (CCRT) has been associated with significant toxicities. aim this study was to assess ability Endostar and amifostine (AM) reduce incidence chemoradiotherapy-induced pneumonitis above grade 2 stage III NSCLC. Patients NSC...

Objective: Disruption of the intestinal epithelial barrier has been shown to occur following burn injury. This process can lead translocation pathogens from gut lumen systemic circulation and distant organs thereby increasing risk for sepsis. The aim this study was examine effect amifostine (WR-2721) on bacterial in a rat injury model. Material Method: A total 27 male Wistar albino rats were di...

In the title compound, (C(3)H(12)N(2))[Zr(C(7)H(3)NO(4))(3)]·3H(2)O, the Zr(IV) cation is chelated by three pyridine-2,6-dicarboxyl-ate anions in a distorted tricapped trigonal-prismatic environment. The crystal structure is stabilized by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

The organic cation in the title compound, C(24)H(32)N(4) (2+)·2Cl(-)·3H(2)O, is situated on an inversion centre. The cations, anions and water mol-ecules are linked via N-H⋯O, N-H⋯Cl, O-H⋯O and O-H⋯Cl hydrogen bonds and C-H⋯π interactions, forming a three-dimensional framework.